Literature DB >> 2878860

Changes in the gastric mucosa of the mouse associated with long lasting unsurmountable histamine H2 blockade.

D Poynter, S A Selway, S A Papworth, S R Riches.   

Abstract

The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related to the prolonged achlorhydria produced by this potent unsurmountable histamine H2 receptor antagonist.

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Year:  1986        PMID： 2878860      PMCID： PMC1434077          DOI： 10.1136/gut.27.11.1338

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  15 in total

1.  Non-A, non-B hepatitis and intravenous immunoglobulin.

Authors:  R P Brettle
Journal:  Lancet       Date:  1985-01-05       Impact factor: 79.321

Review 2.  Endocrine cells of the gastrointestinal tract and related tumors.

Authors:  E Solcia; C Capella; R Buffa; L Usellini; B Frigerio; P Fontana
Journal:  Pathobiol Annu       Date:  1979

3.  Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach.

Authors:  H Goldman; S C Ming
Journal:  Lab Invest       Date:  1968-02       Impact factor: 5.662

4.  Naturally occurring tumors and other lesions of the digestive tract in untreated C57BL mice.

Authors:  C Rowlatt; L M Franks; M U Sheriff; F C Chesterman
Journal:  J Natl Cancer Inst       Date:  1969-12       Impact factor: 13.506

5.  Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats.

Authors:  H Larsson; E Carlsson; H Mattsson; L Lundell; F Sundler; G Sundell; B Wallmark; T Watanabe; R Håkanson
Journal:  Gastroenterology       Date:  1986-02       Impact factor: 22.682

Review 6.  Inhibition of acid and gastric carcinoids.

Authors:  J B Elder
Journal:  Gut       Date:  1985-12       Impact factor: 23.059

7.  Pharmacological basis for the induction of gastric carcinoid tumours in the rat by loxtidine, an insurmountable histamine H2-receptor blocking drug.

Authors:  R T Brittain; D Jack; J J Reeves; R Stables
Journal:  Br J Pharmacol       Date:  1985-08       Impact factor: 8.739

8.  Comparative histochemistry of gastrointestinal mucosubstances.

Authors:  D G Sheahan; H R Jervis
Journal:  Am J Anat       Date:  1976-06

9.  Toxicological studies on omeprazole.

Authors:  L Ekman; E Hansson; N Havu; E Carlsson; C Lundberg
Journal:  Scand J Gastroenterol Suppl       Date:  1985

10.  Neuron specific enolase: a common marker for the endocrine cells and innervation of the gut and pancreas.

Authors:  A E Bishop; J M Polak; P Facer; G L Ferri; P J Marangos; A G Pearse
Journal:  Gastroenterology       Date:  1982-10       Impact factor: 22.682
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  16 in total

1.  Proton pump inhibitors and gastric neoplasia.

Authors:  Helge L Waldum; Gunnar Qvigstad
Journal:  Gut       Date:  2007-07       Impact factor: 23.059

2.  Some possible pathological consequences of peptic ulcer therapy.

Authors:  D Poynter
Journal:  Gut       Date:  1990-02       Impact factor: 23.059

3.  Quantitative electron microscopy of endocrine cells in oxyntic mucosa of normal human stomach.

Authors:  T D'Adda; A Bertelé; F P Pilato; C Bordi
Journal:  Cell Tissue Res       Date:  1989-01       Impact factor: 5.249

Review 4.  Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.

Authors:  Helge L Waldum; Øyvind Hauso; Øystein F Sørdal; Reidar Fossmark
Journal:  Dig Dis Sci       Date:  2014-12-06       Impact factor: 3.199

5.  Argyrophil cell hyperplasia and a carcinoid tumour in the stomach of a patient with sporadic Zollinger-Ellison syndrome.

Authors:  G E Feurle
Journal:  Gut       Date:  1994-02       Impact factor: 23.059

Review 6.  Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis.

Authors:  Reidar Fossmark; Gunnar Qvigstad; Tom Chr Martinsen; Øyvind Hauso; Helge L Waldum
Journal:  J Biomed Biotechnol       Date:  2010-11-24

Review 7.  Gastric cancer: animal studies on the risk of hypoacidity and hypergastrinemia.

Authors:  Reidar Fossmark; Gunnar Qvigstad; Helge-L Waldum
Journal:  World J Gastroenterol       Date:  2008-03-21       Impact factor: 5.742

8.  Gastrin receptor genes are expressed in gastric parietal and enterochromaffin-like cells of Mastomys natalensis.

Authors:  M Asahara; Y Kinoshita; H Nakata; Y Matsushima; Y Naribayashi; A Nakamura; T Matsui; K Chihara; J Yamamoto; A Ichikawa
Journal:  Dig Dis Sci       Date:  1994-10       Impact factor: 3.199

Review 9.  Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases.

Authors:  Marc J Berna; Robert T Jensen
Journal:  Curr Top Med Chem       Date:  2007       Impact factor: 3.295

Review 10.  Therapeutic achlorhydria and risk of gastric cancer.

Authors:  K G Wormsley
Journal:  Gastroenterol Jpn       Date:  1989-10
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