BACKGROUND: Alcohol dependence has been a major cause of treatment non-adherence in tuberculosis (TB) management. There is an urgent need to develop a feasible, acceptable alcohol intervention programme to ensure treatment completion. METHODOLOGY:Four of the 10 Chennai Corporation zones in Chennai, South India, were randomly selected: two each for the experimental and control arms of the study. TB patients registered from August 2013 to January 2014 with the Revised National Tuberculosis Control Programme were assessed using the Alcohol Use Disorder Identification Test (AUDIT) scale. The intervention consisted of four individual counselling sessions at months 0, 2, 4 and 6 conducted by highly trained interventionists. RESULTS: Of 872 TB patients, 298 (31%) were found to have alcohol use disorders. The numbers of TB patients in the experimental and control arms were respectively 113 (38%) and 185 (62%). The proportion of patients with favourable treatment outcomes was higher in the intervention than in the control group (87% vs. 62%, P = 0.04). Overall adherence to anti-tuberculosis treatment was significantly higher in the intervention group (P = 0.02). CONCLUSION: Study findings suggest that alcohol interventions could be effective in ensuring favourable TB treatment outcomes and adherence. This calls for a large cluster randomised trial for greater generalisability. Tested alcohol-intervention strategies should be recommended to promote treatment adherence among TB patients who consume alcohol.
RCT Entities:
BACKGROUND:Alcohol dependence has been a major cause of treatment non-adherence in tuberculosis (TB) management. There is an urgent need to develop a feasible, acceptable alcohol intervention programme to ensure treatment completion. METHODOLOGY: Four of the 10 Chennai Corporation zones in Chennai, South India, were randomly selected: two each for the experimental and control arms of the study. TB patients registered from August 2013 to January 2014 with the Revised National Tuberculosis Control Programme were assessed using the Alcohol Use Disorder Identification Test (AUDIT) scale. The intervention consisted of four individual counselling sessions at months 0, 2, 4 and 6 conducted by highly trained interventionists. RESULTS: Of 872 TB patients, 298 (31%) were found to have alcohol use disorders. The numbers of TB patients in the experimental and control arms were respectively 113 (38%) and 185 (62%). The proportion of patients with favourable treatment outcomes was higher in the intervention than in the control group (87% vs. 62%, P = 0.04). Overall adherence to anti-tuberculosis treatment was significantly higher in the intervention group (P = 0.02). CONCLUSION: Study findings suggest that alcohol interventions could be effective in ensuring favourable TB treatment outcomes and adherence. This calls for a large cluster randomised trial for greater generalisability. Tested alcohol-intervention strategies should be recommended to promote treatment adherence among TB patients who consume alcohol.
Authors: Goedele Louwagie; Mona Kanaan; Neo Keitumetse Morojele; Andre Van Zyl; Andrew Stephen Moriarty; Jinshuo Li; Kamran Siddiqi; Astrid Turner; Noreen Dadirai Mdege; Olufemi Babatunde Omole; John Tumbo; Max Bachmann; Steve Parrott; Olalekan A Ayo-Yusuf Journal: BMJ Open Date: 2022-02-14 Impact factor: 2.692
Authors: Gregory W Wigger; Tara C Bouton; Karen R Jacobson; Sara C Auld; Samantha M Yeligar; Bashar S Staitieh Journal: Front Immunol Date: 2022-03-31 Impact factor: 8.786
Authors: Ramnath Subbaraman; Laura de Mondesert; Angella Musiimenta; Madhukar Pai; Kenneth H Mayer; Beena E Thomas; Jessica Haberer Journal: BMJ Glob Health Date: 2018-10-11
Authors: Beena E Thomas; Ramnath Subbaraman; Chandra Suresh; J Lavanya; Mika M Lindsley; Amith T Galivanche; Senthil Sellappan; Senthanro Ovung; Amritha Aravind; Savari Lincy; Agnes Lawrence Raja; S Kokila; B Javeed; S Arumugam; Kenneth H Mayer; Soumya Swaminathan Journal: BMJ Glob Health Date: 2020-03-02