Literature DB >> 28786181

Survival and laryngeal preservation tradeoff in advanced laryngeal cancer: From the otorhinolaryngology patient to the managing physician.

Ollivier Laccourreye1, Pierre Bonfils1, David Malinvaud1, Madeleine Ménard1, Philippe Giraud2.   

Abstract

BACKGROUND: The purpose of this study was to document the tradeoff between survival and laryngeal preservation in advanced-stage laryngeal cancer amenable to chemoradiation or total laryngectomy.
METHODS: We conducted a prospective analysis based on a questionnaire completed by 209 laryngeal cancer specialists and 269 volunteers from an otorhinolaryngology clinic.
RESULTS: Of the responders, 34.5% would not consider any decrease in survival to preserve their larynx. This percentage varied from 52% in otorhinolaryngologists to 27.3% in radiotherapists and 28.6% in volunteers (P < .001). Among the responders prepared to trade, the percentage of survival they were willing to trade to preserve their larynx varied from 5% to 100% (median 30%). On univariate analysis, 3 variables significantly affected this percentage: (1) the living status (single or not); (2) the existence of children; and (3) the study group (volunteers, radiation therapists, or otorhinolaryngologists) to whom the responders belong.
CONCLUSION: The significant variations noted should develop modes of practice that cater to this and stimulate further research in this field.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  laryngeal cancer; organ preservation; tradeoff

Mesh:

Year:  2017        PMID: 28786181     DOI: 10.1002/hed.24833

Source DB:  PubMed          Journal:  Head Neck        ISSN: 1043-3074            Impact factor:   3.147


  1 in total

1.  lncRNA SOX2-OT regulates laryngeal cancer cell proliferation, migration and invasion and induces apoptosis by suppressing miR-654.

Authors:  Guang Li; Chunchen Pan; Jiaqiang Sun; Guanglun Wan; Jingwu Sun
Journal:  Exp Ther Med       Date:  2020-03-06       Impact factor: 2.447

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.