Usha Gurunathan1, Simone Ramsay2, Goran Mitrić2, Mandy Way3, Leesa Wockner3, Paul Myles4. 1. Department of Anaesthesia and Perfusion Services & Department of Surgery, The Prince Charles Hospital & University of Queensland, Rode Road, Chermside, Brisbane, QLD, Australia. usha.gurunathan@health.qld.gov.au. 2. Department of Anaesthesia and Perfusion Services & Department of Surgery, The Prince Charles Hospital & University of Queensland, Rode Road, Chermside, Brisbane, QLD, Australia. 3. Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Australia. 4. Department of Anaesthesia and Perioperative Medicine, Alfred Hospital & Monash University, Melbourne, Australia.
Abstract
BACKGROUND: The aim of this meta-analysis is to comprehensively review and quantify the excess risk of surgical site infections (SSI) in obese patients following colorectal surgery. METHODS: A systematic electronic search of the MEDLINE and EMBASE databases identified studies that investigated the association of obesity, defined by body mass index (BMI) with SSI among colorectal surgery patients. RESULTS: Twelve studies were included in the final analysis. Patients with BMI ≥30 kg/m2 were at 1.5 times (pooled OR 1.51, 95% CI: 1.39, 1.63, p < 0.001) higher odds of developing SSI after colorectal surgery when compared to BMI <30 kg/m2. Subgroup analysis of the eight studies that investigated only elective procedures showed that the odds of developing SSI when BMI ≥30 kg/m2 is 1.6 times that of those with BMI <30 kg/m2 (pooled OR 1.60; 95% CI 1.34, 1.86; p < 0.001). The odds of having SSI when BMI is 25-29.9 kg/m2 are 1.2 times than those with BMI <25 kg/m2 (pooled OR 1.17; 95% CI 1.07, 1.28; p < 0.001). CONCLUSION: Overweight and obese patients carry at least 20% and 50% higher odds of developing SSI after colorectal surgery compared to normal weight patients, respectively.
BACKGROUND: The aim of this meta-analysis is to comprehensively review and quantify the excess risk of surgical site infections (SSI) in obesepatients following colorectal surgery. METHODS: A systematic electronic search of the MEDLINE and EMBASE databases identified studies that investigated the association of obesity, defined by body mass index (BMI) with SSI among colorectal surgery patients. RESULTS: Twelve studies were included in the final analysis. Patients with BMI ≥30 kg/m2 were at 1.5 times (pooled OR 1.51, 95% CI: 1.39, 1.63, p < 0.001) higher odds of developing SSI after colorectal surgery when compared to BMI <30 kg/m2. Subgroup analysis of the eight studies that investigated only elective procedures showed that the odds of developing SSI when BMI ≥30 kg/m2 is 1.6 times that of those with BMI <30 kg/m2 (pooled OR 1.60; 95% CI 1.34, 1.86; p < 0.001). The odds of having SSI when BMI is 25-29.9 kg/m2 are 1.2 times than those with BMI <25 kg/m2 (pooled OR 1.17; 95% CI 1.07, 1.28; p < 0.001). CONCLUSION: Overweight and obesepatients carry at least 20% and 50% higher odds of developing SSI after colorectal surgery compared to normal weight patients, respectively.
Entities:
Keywords:
Colorectal surgery; Obesity; Surgical site infection
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