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Literature DB >> 28784589

Flavin-N5-oxide: A new, catalytic motif in flavoenzymology.

Abstract

Flavin-N5-oxide is a recently discovered intermediate used by EncM (1,3-diketone oxidation), DszA (sulfone monooxygenase) and RutA (amide monooxygenase). This review describes the mechanism of these enzymes and proposes criteria for the identification of additional Flavin-N5-oxide dependent enzymes.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2017 PMID： 28784589 PMCID： PMC6037421 DOI： 10.1016/j.abb.2017.08.001

Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013

17 in total

Review 1. Biodesulfurization of refractory organic sulfur compounds in fossil fuels.

Authors: Mehran Soleimani; Amarjeet Bassi; Argyrios Margaritis
Journal: Biotechnol Adv Date: 2007-07-31 Impact factor: 14.227

2. Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.

Authors: Robin Teufel; Frederick Stull; Michael J Meehan; Quentin Michaudel; Pieter C Dorrestein; Bruce Palfey; Bradley S Moore
Journal: J Am Chem Soc Date: 2015-06-19 Impact factor: 15.419

Review 3. Sweating the assets of flavin cofactors: new insight of chemical versatility from knowledge of structure and mechanism.

Authors: David Leys; Nigel S Scrutton
Journal: Curr Opin Struct Biol Date: 2016-06-03 Impact factor: 6.809

Review 4. Flavins as Covalent Catalysts: New Mechanisms Emerge.

Authors: Valentina Piano; Bruce A Palfey; Andrea Mattevi
Journal: Trends Biochem Sci Date: 2017-03-06 Impact factor: 13.807

5. EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions.

Authors: Longkuan Xiang; John A Kalaitzis; Bradley S Moore
Journal: Proc Natl Acad Sci U S A Date: 2004-10-25 Impact factor: 11.205

Flavin-N5-oxide: A new, catalytic motif in flavoenzymology.

Review 1. Biodesulfurization of refractory organic sulfur compounds in fossil fuels.

2. Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor.

Review 3. Sweating the assets of flavin cofactors: new insight of chemical versatility from knowledge of structure and mechanism.

Review 4. Flavins as Covalent Catalysts: New Mechanisms Emerge.

5. EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions.

6. Dibenzothiophene Catabolism Proceeds via a Flavin-N5-oxide Intermediate.

7. A previously undescribed pathway for pyrimidine catabolism.

Review 8. Unusual flavoenzyme catalysis in marine bacteria.

9. Molecular mechanisms of biocatalytic desulfurization of fossil fuels.

10. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.

1. Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.

2. Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B.

Review 3. Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities.