| Literature DB >> 28783936 |
Sung-Jin Kim1, Jung-Min Kim1, Joo-Cheol Shim2, Beom-Joo Seo3, Sung-Soo Jung4, Jeoung-Whan Ryu5, Young-Soo Seo4, Yu-Cheol Lee3, Jung-Joon Moon1, Dong-Wook Jeon1, Kyoung-Duck Park4, Do-Un Jung1.
Abstract
OBJECTIVE: The study's aim was to develop and standardize a Korean version of the University of California San Diego Performance-based Skills Assessment (K-UPSA), which is used to evaluate the daily living function of patients with schizophrenia.Entities:
Keywords: Cognitive function; Reliability; Schizophrenia; Validity
Year: 2017 PMID: 28783936 PMCID: PMC5565087 DOI: 10.9758/cpn.2017.15.3.261
Source DB: PubMed Journal: Clin Psychopharmacol Neurosci ISSN: 1738-1088 Impact factor: 2.582
Demographic and clinical characteristics of patients with schizophrenia and controls
| Characteristic | Patient (n=78) | Control (n=27) | |
|---|---|---|---|
| Gender | |||
| Male | 46 (59.0) | 14 (51.9) | 0.519 |
| Female | 32 (41.0) | 13 (48.1) | |
| Age (yr) | 37.12±10.08 | 37.11±9.42 | 0.998 |
| Education (yr) | 13.03±1.68 | 13.33±1.18 | 0.050 |
| Duration of illness (mo) | 171.92±113.74 | ||
| Average daily neuroleptic dose (mg, CPZE) | 625.60±342.25 | ||
| PANSS | |||
| Positive subscale | 15.42±6.25 | ||
| Negative subscale | 15.49±6.27 | ||
| General psychopathology subscale | 31.87±9.49 | ||
| Total score | 62.78±19.36 | ||
| CGI-SCH | |||
| Positive symptoms | 3.17±1.35 | ||
| Negative symptoms | 2.47±1.20 | ||
| Depressive symptoms | 1.99±1.05 | ||
| Cognitive symptoms | 2.58±1.22 | ||
| Overall severity | 2.92±1.03 | ||
| SQLS | 29.39±20.42 | ||
| SOFAS | 52.95±11.49 | ||
Values are presented number (%) or mean±standard deviation.
Chi-square test;
Student’s t test;
Mann-Whitney test.
CPZE, chlorpromazine equivalent; PANSS, Positive and Negative Syndrome Scale; CGI-SCH, Clinical Global Impression-Schizophrenia scale; SQLS, Schizophrenia Quality of Life Scale; SOFAS, Social and Occupational Functioning Assessment Scale.
Comparison of patients with schizophrenia and controls in cognitive measures
| Schizophrenic (n=78) | Control (n=27) | Z or t score | ||
|---|---|---|---|---|
| K-UPSA | ||||
| Financial | 15.86±3.91 | 19.63±0.79 | 6.044 | <0.001 |
| Communication | 11.04±4.34 | 16.78±1.63 | 6.181 | <0.001 |
| Comprehension/planning | 9.47±4.24 | 16.00±3.15 | 6.159 | <0.001 |
| Transportation | 14.01±4.86 | 19.56±1.01 | 5.856 | <0.001 |
| Household skills | 15.83±6.81 | 19.81±0.96 | 3.240 | 0.001 |
| Total score | 66.19±17.89 | 91.63±3.96 | 7.354 | <0.001 |
| K-WAIS | 92.88±12.02 | 108.44±11.85 | 5.726 | <0.001* |
| WCST | ||||
| PR | 39.27±26.87 | 25.95±17.40 | 2.322 | 0.020 |
| PE | 32.33±19.63 | 22.05±13.17 | 2.379 | 0.017 |
| CA | 1.55±1.90 | 3.68±2.34 | 3.645 | <0.001 |
| SCoRS | ||||
| Patient | 35.24±11.22 | 22.63±4.20 | 5.827 | <0.001 |
| Informant | 35.23±12.11 | 22.63±4.20 | 5.596 | <0.001 |
| Interviewer | 37.27±11.89 | 21.22±1.97 | 6.864 | <0.001 |
| Global rating | 4.31±2.06 | 1.11±0.32 | 7.201 | <0.001 |
Values are presented as mean±standard deviation.
Using Mann-Whitney test (*Student’s t test).
K-UPSA, the Korean version of the University of California San Diego Performance-based Skills Assessment; K-WAIS, Short-form of Korean-Wechsler Adult Intelligence Scale; WCST, Wisconsin Card Sorting Test; PR, perseverative responses; PE, perseverative errors; CA, numbers of categories achieved; SCoRS, Schizophrenia Cognitive Rating Scale.
Correlations between the K-UPSA and demographic/clinical characteristics in patients with schizophrenia (n=78)
| Financial | Communication | Comprehension/planning | Transportation | Household skills | Total score | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
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| r | r | r | r | r | r | |||||||
| Age | −0.154 | 0.118 | −0.214 | 0.028 | −0.265 | 0.006 | −0.193 | 0.049 | −0.123 | 0.210 | −0.240 | 0.014 |
| Education | 0.260 | 0.007 | 0.184 | 0.061 | 0.109 | 0.267 | 0.125 | 0.204 | 0.144 | 0.141 | 0.204 | 0.037 |
| Duration of illness | −0.205 | 0.072 | −0.239 | 0.035 | −0.189 | 0.097 | −0.209 | 0.067 | −0.183 | 0.108 | −0.278 | 0.014 |
| CPZE | 0.204 | 0.075 | 0.052 | 0.655 | 0.100 | 0.386 | 0.171 | 0.138 | 0.120 | 0.300 | 0.175 | 0.127 |
| PANSS | ||||||||||||
| Positive | −0.133 | 0.244 | −0.140 | 0.222 | −0.125 | 0.276 | −0.244 | 0.031 | −0.262 | 0.021 | −0.258 | 0.022 |
| Negative | −0.309 | 0.006 | −0.225 | 0.048 | 0.038 | 0.741 | −0.342 | 0.002 | −0.242 | 0.033 | −0.297 | 0.008 |
| General | −0.178 | 0.119 | −0.182 | 0.111 | −0.052 | 0.649 | −0.213 | 0.061 | −0.305 | 0.007 | −0.269 | 0.017 |
| Total | −0.231 | 0.042 | −0.207 | 0.069 | −0.054 | 0.641 | −0.294 | 0.009 | −0.312 | 0.005 | −0.311 | 0.006 |
| CGI-SCH | ||||||||||||
| Positive symptoms | 0.004 | 0.969 | −0.134 | 0.243 | −0.030 | 0.795 | −0.198 | 0.082 | −0.290 | 0.010 | −0.200 | 0.078 |
| Negative symptoms | −0.088 | 0.445 | −0.225 | 0.048 | 0.072 | 0.528 | −0.185 | 0.104 | −0.104 | 0.363 | −0.147 | 0.200 |
| Depressive symptoms | 0.015 | 0.894 | −0.210 | 0.064 | −0.013 | 0.909 | −0.183 | 0.109 | −0.180 | 0.115 | −0.168 | 0.140 |
| Cognitive symptoms | −0.390 | <0.001 | −0.415 | <0.001 | −0.199 | 0.081 | −0.557 | 0.000 | −0.347 | 0.002 | −0.518 | <0.001 |
| Overall severity | −0.216 | 0.058 | −0.360 | 0.001 | −0.120 | 0.297 | −0.394 | 0.000 | −0.315 | 0.005 | −0.387 | <0.001 |
| SQLS | −0.213 | 0.048 | −0.262 | 0.014 | −0.250 | 0.020 | −0.269 | 0.012 | −0.300 | 0.005 | −0.338 | 0.001 |
| SOFAS | 0.129 | 0.262 | 0.291 | 0.010 | 0.230 | 0.043 | 0.280 | 0.013 | 0.313 | 0.005 | 0.345 | 0.002 |
K-UPSA, the Korean version of the University of California San Diego Performance-based Skills Assessment; CGI-SCH, Clinical Global Impression-Schizophrenia scale; CPZE, chlorpromazine equivalent; PANSS, Positive and Negative Syndrome Scale; SQLS, Schizophrenia Quality of Life Scale; SOFAS, Social and Occupational Functioning Assessment Scale.
Correlations between the K-UPSA and cognitive functions in patients with schizophrenia (n=78)
| Financial | Communication | Comprehension/planning | Transportation | Household skills | Total score | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| r | r | r | r | r | r | |||||||
| K-WAIS | 0.582 | <0.001 | 0.607 | <0.001 | 0.467 | <0.001 | 0.520 | <0.001 | 0.348 | 0.001 | 0.615 | <0.001 |
| WCST | ||||||||||||
| PR | −0.014 | 0.895 | −0.271 | 0.010 | −0.190 | 0.074 | −0.013 | 0.905 | 0.000 | 0.997 | −0.122 | 0.256 |
| PE | −0.034 | 0.751 | −0.273 | 0.010 | −0.199 | 0.061 | −0.031 | 0.771 | −0.003 | 0.978 | −0.134 | 0.212 |
| CA | 0.316 | 0.003 | 0.442 | <0.001 | 0.351 | 0.001 | 0.353 | 0.001 | 0.272 | 0.010 | 0.429 | <0.001 |
| SCoRS | ||||||||||||
| Patient | −0.389 | <0.001 | −0.533 | <0.001 | −0.435 | <0.001 | −0.517 | <0.001 | −0.338 | <0.001 | −0.556 | <0.001 |
| Informant | −0.487 | <0.001 | −0.538 | <0.001 | −0.351 | <0.001 | −0.592 | <0.001 | −0.464 | <0.001 | −0.618 | <0.001 |
| Interviewer | −0.525 | <0.001 | −0.626 | <0.001 | −0.450 | <0.001 | −0.618 | <0.001 | −0.473 | <0.001 | −0.677 | <0.001 |
| Global rating | −0.544 | <0.001 | −0.588 | <0.001 | −0.420 | <0.001 | −0.594 | <0.001 | −0.463 | <0.001 | −0.653 | <0.001 |
K-UPSA, the Korean version of the University of California San Diego Performance-based Skills Assessment; K-WAIS, Short-form of Korean-Wechsler Adult Intelligence Scale; WCST, Wisconsin Card Sorting Test; PR, perseverative responses; PE, perseverative errors; CA, numbers of categories achieved; SCoRS, Schizophrenia Cognitive Rating Scale.
Test-retest reliability (n=76)
| K-UPSA | Baseline | Follow-up | ICC | 95% CI | |
|---|---|---|---|---|---|
| Financial | 16.83±3.77 | 17.73±3.47 | 0.756 | 0.660–0.827 | <0.001 |
| Communication | 12.51±4.58 | 13.40±4.48 | 0.738 | 0.637–0.814 | <0.001 |
| Comprehension/planning | 11.15±4.90 | 12.37±5.16 | 0.662 | 0.540–0.757 | <0.001 |
| Transportation | 15.44±4.87 | 15.92±4.39 | 0.672 | 0.552–0.765 | <0.001 |
| Household skills | 16.86±6.13 | 18.05±5.26 | 0.381 | 0.206–0.533 | <0.001 |
| Total score | 72.73±19.12 | 77.42±18.02 | 0.792 | 0.708–0.854 | <0.001 |
K-UPSA, the Korean version of the University of California San Diego Performance-based Skills Assessment; ICC, intraclass correlation coefficient; CI, confidence interval.