Literature DB >> 28783356

Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.

Hai X Nguyen, Mai T T Nguyen, Nhan T Nguyen, Suresh Awale1.   

Abstract

The ethanol extract of propolis from the Vietnamese stingless bee Trigona minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium, with a PC50 value of 14.0 μg/mL. Chemical investigation of this extract led to the isolation of 15 cycloartane-type triterpenoids, including five new compounds (1-5), and a lanostane-type triterpenoid. The structures of the new compounds were elucidated on the basis of NMR spectroscopic analysis. Among the isolated compounds, 23-hydroxyisomangiferolic acid B (5) and 27-hydroxyisomangiferolic acid (13) exhibited the most potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 4.3 and 3.7 μM, respectively.

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Year:  2017        PMID： 28783356     DOI： 10.1021/acs.jnatprod.7b00375

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Propolis: An update on its chemistry and pharmacological applications.

Authors:  Rajib Hossain; Cristina Quispe; Rasel Ahmed Khan; Abu Saim Mohammad Saikat; Pranta Ray; Damira Ongalbek; Balakyz Yeskaliyeva; Divya Jain; Antonella Smeriglio; Domenico Trombetta; Roghayeh Kiani; Farzad Kobarfard; Naheed Mojgani; Parvaneh Saffarian; Seyed Abdulmajid Ayatollahi; Chandan Sarkar; Mohammad Torequl Islam; Dılhun Keriman; Arserim Uçar; Miquel Martorell; Antoni Sureda; Gianfranco Pintus; Monica Butnariu; Javad Sharifi-Rad; William C Cho
Journal:  Chin Med       Date:  2022-08-26       Impact factor: 4.546

2.  Computational Study of Asian Propolis Compounds as Potential Anti-Type 2 Diabetes Mellitus Agents by Using Inverse Virtual Screening with the DIA-DB Web Server, Tanimoto Similarity Analysis, and Molecular Dynamic Simulation.

Authors:  Putri Hawa Syaifie; Azza Hanif Harisna; Mochammad Arfin Fardiansyah Nasution; Adzani Gaisani Arda; Dwi Wahyu Nugroho; Muhammad Miftah Jauhar; Etik Mardliyati; Nurwenda Novan Maulana; Nurul Taufiqu Rochman; Alfian Noviyanto; Antonio J Banegas-Luna; Horacio Pérez-Sánchez
Journal:  Molecules       Date:  2022-06-21       Impact factor: 4.927

Review 3.  Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions.

Authors:  Mohammad A I Al-Hatamleh; Jennifer C Boer; Kirsty L Wilson; Magdalena Plebanski; Rohimah Mohamud; Mohd Zulkifli Mustafa
Journal:  Biomolecules       Date:  2020-06-18

4.  Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line.

Authors:  Mostafa Alilou; Dya Fita Dibwe; Stefan Schwaiger; Mojtaba Khodami; Jakob Troppmair; Suresh Awale; Hermann Stuppner
Journal:  J Nat Prod       Date:  2020-03-12       Impact factor: 4.050

5.  Phytochemical analysis of Vietnamese propolis produced by the stingless bee Lisotrigona cacciae.

Authors:  Kristina Georgieva; Milena Popova; Lyudmila Dimitrova; Boryana Trusheva; Le Nguyen Thanh; Diep Thi Lan Phuong; Nguyen Thi Phuong Lien; Hristo Najdenski; Vassya Bankova
Journal:  PLoS One       Date:  2019-04-24       Impact factor: 3.240

6.  Cycloartane-Type Triterpenes and Botanical Origin of Propolis of Stingless Indonesian Bee Tetragonula sapiens.

Authors:  Niken Pujirahayu; Toshisada Suzuki; Takeshi Katayama
Journal:  Plants (Basel)       Date:  2019-03-08

7.  Mangifera indica as propolis source: what exactly do bees collect?

Authors:  Milena Popova; Boryana Trusheva; Nia Ilieva; Le Nguyen Thanh; Nguyen Thi Phuong Lien; Vassya Bankova
Journal:  BMC Res Notes       Date:  2021-12-13

Review 8.  Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components.

Authors:  Trong D Tran; Steven M Ogbourne; Peter R Brooks; Norberto Sánchez-Cruz; José L Medina-Franco; Ronald J Quinn
Journal:  Int J Mol Sci       Date:  2020-07-15       Impact factor: 5.923

Review 9.  Stingless Bee Propolis: New Insights for Anticancer Drugs.

Authors:  Jaqueline Ferreira Campos; Helder Freitas Dos Santos; Thaliny Bonamigo; Nelson Luís de Campos Domingues; Kely de Picoli Souza; Edson Lucas Dos Santos
Journal:  Oxid Med Cell Longev       Date:  2021-09-23       Impact factor: 6.543
  9 in total

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