Literature DB >> 28782090

Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus.

Christopher D Phillips1, Pornpatcharin Wongsaisri2, Thein Htut2, Terry Grossman3,4.   

Abstract

INTRODUCTION: Systemic lupus erythematosus (SLE) is a multiple organ system autoimmune disorder for which there is no known cure.
METHODS: We report a case of a young adult lady with SLE and Sjogren's with diagnostic and clinical resolution following purified umbilical cord derived mesenchymal stem cell (MSC) and globulin component protein macrophage activating factor (GcMAF) therapy in a combined multidisciplinary integrative medicine protocol.
RESULTS: Our patient had complete reversal of all clinical and laboratory markers.
CONCLUSION: We recommend a prospective randomized double blind study to assess the sustained efficacy of MSC and GcMAF in the treatment of autoimmune connective tissue diseases such as systemic lupus erythematosus.

Entities:  

Keywords:  Autoimmune diseases; Connective tissue diseases; Lupus; Mesenchymal stem cells; Sjogren’s; Systemic lupus erythematosus; Systemic sclerosis; gcMAF

Year:  2017        PMID: 28782090     DOI: 10.1186/s40169-017-0161-6

Source DB:  PubMed          Journal:  Clin Transl Med        ISSN: 2001-1326


  9 in total

Review 1.  Immunoregulatory function of mesenchymal stem cells.

Authors:  Antonio Uccelli; Lorenzo Moretta; Vito Pistoia
Journal:  Eur J Immunol       Date:  2006-10       Impact factor: 5.532

2.  Case Report: GcMAF Treatment in a Patient with Multiple Sclerosis.

Authors:  Toshio Inui; Goro Katsuura; Kentaro Kubo; Daisuke Kuchiike; Leslye Chenery; Yoshihiro Uto; Takahito Nishikata; Martin Mette
Journal:  Anticancer Res       Date:  2016-07       Impact factor: 2.480

3.  Interaction of exercise and ethanol on antioxidant enzymes in brain regions of the rat.

Authors:  S M Somani; K Husain; L Diaz-Phillips; D J Lanzotti; K R Kareti; G L Trammell
Journal:  Alcohol       Date:  1996 Nov-Dec       Impact factor: 2.405

4.  Deglycosylation of serum vitamin D3-binding protein by alpha-N-acetylgalactosaminidase detected in the plasma of patients with systemic lupus erythematosus.

Authors:  N Yamamoto; V R Naraparaju; M Moore; L H Brent
Journal:  Clin Immunol Immunopathol       Date:  1997-03

5.  Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients.

Authors:  Ricard Cervera; Munther A Khamashta; Josep Font; Gian Domenico Sebastiani; Antonio Gil; Paz Lavilla; Juan Carlos Mejía; A Olcay Aydintug; Hanna Chwalinska-Sadowska; Enrique de Ramón; Antonio Fernández-Nebro; Mauro Galeazzi; Merete Valen; Alessandro Mathieu; Frédéric Houssiau; Natividad Caro; Paula Alba; Manuel Ramos-Casals; Miguel Ingelmo; Graham R V Hughes
Journal:  Medicine (Baltimore)       Date:  2003-09       Impact factor: 1.889

6.  Clinical experience of integrative cancer immunotherapy with GcMAF.

Authors:  Toshio Inui; Daisuke Kuchiike; Kentaro Kubo; Martin Mette; Yoshihiro Uto; Hitoshi Hori; Norihiro Sakamoto
Journal:  Anticancer Res       Date:  2013-07       Impact factor: 2.480

Review 7.  Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.

Authors:  Giselle Chamberlain; James Fox; Brian Ashton; Jim Middleton
Journal:  Stem Cells       Date:  2007-07-26       Impact factor: 6.277

8.  Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study.

Authors:  Dandan Wang; Jing Li; Yu Zhang; Miaojia Zhang; Jinyun Chen; Xia Li; Xiang Hu; Shu Jiang; Songtao Shi; Lingyun Sun
Journal:  Arthritis Res Ther       Date:  2014-03-25       Impact factor: 5.156

Review 9.  Update on mesenchymal stem cell-based therapy in lupus and scleroderma.

Authors:  Audrey Cras; Dominique Farge; Thierry Carmoi; Jean-Jacques Lataillade; Dan Dan Wang; Lingyun Sun
Journal:  Arthritis Res Ther       Date:  2015-11-03       Impact factor: 5.156

  9 in total
  2 in total

1.  Retraction Note: Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus.

Authors:  Christopher D Phillips; Pornpatcharin Wongsaisri; Thein Htut; Terry Grossman
Journal:  Clin Transl Med       Date:  2018-09-14

2.  Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Authors:  Nannan Yan; Jie Xu; Chuanxiang Zhao; Yi Wu; Fengwei Gao; Ci Li; Wenhui Zhou; Tengfei Xiao; Xiaoming Zhou; Qixiang Shao; Sheng Xia
Journal:  Exp Ther Med       Date:  2018-09-19       Impact factor: 2.447

  2 in total

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