Literature DB >> 28781799

Long non-coding RNA HOTTIP is able to predict poor prognosis in various neoplasms: A meta-analysis.

Ning Jin1, Ling-Yun Yang2, Zi-Peng Xu3.   

Abstract

HOXA distal transcript antisense RNA (HOTTIP), a critical oncogenic long non-coding RNA, has been reported to be aberrantly regulated in various cancer types. The present meta-analysis aimed to investigate HOTTIP as a potential clinical applicable prognostic biomarker in malignant neoplasms. Literature collections were performed by searching the electronic databases, PubMed and Web of Science (up to July 20, 2016). All the relevant searches were conducted to identify the association of HOTTIP with the overall survival (OS) rate. A total of six articles consisting of 508 patients were included in the present meta-analysis. The results suggested that the overexpression of HOTTIP is closely correlated with poor OS (hazard ratio=2.28; 95% confidence interval=1.71-3.04; P=0.000). In conclusion, the present meta-analysis has demonstrated that an increased expression level of HOTTIP is correlated with poor OS in different types of cancer, suggesting that HOTTIP potentially serves as a reliable prognostic biomarker in different types of cancer.

Entities:  

Keywords:  HOTTIP; HOXA distal transcript antisense RNA; cancer; long non-coding RNA; meta-analysis; prognosis

Year:  2017        PMID： 28781799      PMCID： PMC5532693          DOI： 10.3892/mco.2017.1293

Source DB:  PubMed          Journal:  Mol Clin Oncol        ISSN： 2049-9450


  19 in total

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Journal:  Nat Struct Mol Biol       Date:  2015-01       Impact factor: 15.369

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Journal:  Hepatology       Date:  2014-01-28       Impact factor: 17.425

4.  A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.

Authors:  Kevin C Wang; Yul W Yang; Bo Liu; Amartya Sanyal; Ryan Corces-Zimmerman; Yong Chen; Bryan R Lajoie; Angeline Protacio; Ryan A Flynn; Rajnish A Gupta; Joanna Wysocka; Ming Lei; Job Dekker; Jill A Helms; Howard Y Chang
Journal:  Nature       Date:  2011-03-20       Impact factor: 49.962

5.  LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b.

Authors:  Yuan Gao; Hao Meng; Shupeng Liu; Jingjing Hu; Yemin Zhang; Tingting Jiao; Yujie Liu; Jun Ou; Dan Wang; Lin Yao; Shanrong Liu; Ning Hui
Journal:  Hum Mol Genet       Date:  2014-10-06       Impact factor: 6.150

6.  Long noncoding RNA HOTTIP contributes to the progression of prostate cancer by regulating HOXA13.

Authors:  S-R Zhang; J-K Yang; J-K Xie; L-C Zhao
Journal:  Cell Mol Biol (Noisy-le-grand)       Date:  2016-03-31       Impact factor: 1.770

7.  MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma.

Authors:  Yunxia Ge; Xiaodan Yan; Yiguang Jin; Xinyu Yang; Xiang Yu; Liqing Zhou; Sichong Han; Qipeng Yuan; Ming Yang
Journal:  PLoS Genet       Date:  2015-12-28       Impact factor: 5.917

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Authors:  Youyou Zhang; Qun He; Zhongyi Hu; Yi Feng; Lingling Fan; Zhaoqing Tang; Jiao Yuan; Weiwei Shan; Chunsheng Li; Xiaowen Hu; Janos L Tanyi; Yi Fan; Qihong Huang; Kathleen Montone; Chi V Dang; Lin Zhang
Journal:  Nat Struct Mol Biol       Date:  2016-04-25       Impact factor: 15.369

10.  Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer.

Authors:  Sophie Sw Wang; Kenly Wuputra; Chung-Jung Liu; Yin-Chu Lin; Yi-Ting Chen; Chee-Yin Chai; Chen-Lung Steve Lin; Kung-Kai Kuo; Ming-Ho Tsai; Shin-Wei Wang; Ker-Kong Chen; Hiroyuki Miyoshi; Yukio Nakamura; Shigeo Saito; Tadashi Hanafusa; Deng-Chyang Wu; Chang-Shen Lin; Kazunari K Yokoyama
Journal:  Oncotarget       Date:  2016-06-14
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  3 in total

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Authors:  Shidai Mu; Lisha Ai; Chunyan Sun; Yu Hu; Fengjuan Fan
Journal:  Cancer Cell Int       Date:  2018-01-03       Impact factor: 5.722

Review 2.  The Role of Long Non-Coding RNAs in Hepatocarcinogenesis.

Authors:  Manuela Lanzafame; Gaia Bianco; Luigi M Terracciano; Charlotte K Y Ng; Salvatore Piscuoglio
Journal:  Int J Mol Sci       Date:  2018-02-28       Impact factor: 5.923

3.  Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia.

Authors:  Laura M Kettyle; Charles-Étienne Lebert-Ghali; Ivan V Grishagin; Glenda J Dickson; Paul G O'Reilly; David A Simpson; Janet J Bijl; Ken I Mills; Guy Sauvageau; Alexander Thompson
Journal:  Cancers (Basel)       Date:  2019-12-17       Impact factor: 6.639
  3 in total

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