AIMS: The aim of this report was to examine the effect of underexpansion on stent thrombogenicity with an in vitro perfusion model. METHODS AND RESULTS: Drug-eluting stent (DES) samples were partially underdeployed in silicone tubes and perfused with porcine blood containing 10% anticoagulant citrate dextrose solution for four minutes at a flow rate of 200 ml/min. Thrombus formation was evaluated and compared between the well-apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well-apposed sections (13.9 vs. 0.41 mm2, p<0.001). CONCLUSIONS: Stent malapposition has a very direct impact on thrombus formation. Optimised stent implantation is required to minimise malapposition in DES and BVS to reduce thrombus formation.
AIMS: The aim of this report was to examine the effect of underexpansion on stent thrombogenicity with an in vitro perfusion model. METHODS AND RESULTS: Drug-eluting stent (DES) samples were partially underdeployed in silicone tubes and perfused with porcine blood containing 10% anticoagulant citrate dextrose solution for four minutes at a flow rate of 200 ml/min. Thrombus formation was evaluated and compared between the well-apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well-apposed sections (13.9 vs. 0.41 mm2, p<0.001). CONCLUSIONS: Stent malapposition has a very direct impact on thrombus formation. Optimised stent implantation is required to minimise malapposition in DES and BVS to reduce thrombus formation.
Authors: Pawel Gasior; Shengjie Lu; Chen Koon Jaryl Ng; Wee Yee Daniel Toong; En Hou Philip Wong; Nicolas Foin; Elvin Kedhi; Wojciech Wojakowski; Hui Ying Ang Journal: Sci Rep Date: 2020-11-27 Impact factor: 4.379