Literature DB >> 28781061

Dissecting Glioma Invasiveness in a 3D-Organotypic Model.

Paolo Codega1, Ingo K Mellinghoff2.   

Abstract

Diffuse brain infiltration by tumor cells is a hallmark of glioma. Molecular mechanisms of brain invasion are poorly understood due to the difficulty to model this process in culture. A new study published in Cell Reports developed a three-dimensional organotypic model and identified interferon regulatory factor 3 (IRF3) as repressor of glioma invasion.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28781061      PMCID： PMC5588876          DOI： 10.1016/j.molmed.2017.07.009

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

1.  Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.

Authors:  Min Du; Jinghua Liu; Xia Chen; Yadong Xie; Chuanping Yuan; Yu Xiang; Bing Sun; Ke Lan; Mingzhou Chen; Sharmy J James; Yongliang Zhang; Jin Zhong; Hui Xiao
Journal:  J Immunol       Date:  2015-03-25       Impact factor: 5.422

Review 2.  Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues.

Authors:  Brendon M Baker; Christopher S Chen
Journal:  J Cell Sci       Date:  2012-07-13       Impact factor: 5.285

Review 3.  Cancer invasion and the microenvironment: plasticity and reciprocity.

Authors:  Peter Friedl; Stephanie Alexander
Journal:  Cell       Date:  2011-11-23       Impact factor: 41.582

4.  CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy.

Authors:  Adam Siddiqui-Jain; Denis Drygin; Nicole Streiner; Peter Chua; Fabrice Pierre; Sean E O'Brien; Josh Bliesath; Mayuko Omori; Nanni Huser; Caroline Ho; Chris Proffitt; Michael K Schwaebe; David M Ryckman; William G Rice; Kenna Anderes
Journal:  Cancer Res       Date:  2010-12-15       Impact factor: 12.701

5.  Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness.

Authors:  Nora Pencheva; Mark C de Gooijer; Daniel J Vis; Lodewyk F A Wessels; Tom Würdinger; Olaf van Tellingen; René Bernards
Journal:  Cell Rep       Date:  2017-07-05       Impact factor: 9.423

Review 6.  Adult Glioblastoma.

Authors:  Brian M Alexander; Timothy F Cloughesy
Journal:  J Clin Oncol       Date:  2017-06-22       Impact factor: 44.544

7.  Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotype.

Authors:  Baisakhi Raychaudhuri; Yulong Han; Tao Lu; Michael A Vogelbaum
Journal:  J Neurooncol       Date:  2007-05-04       Impact factor: 4.130

8.  Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.

Authors:  Heidi S Phillips; Samir Kharbanda; Ruihuan Chen; William F Forrest; Robert H Soriano; Thomas D Wu; Anjan Misra; Janice M Nigro; Howard Colman; Liliana Soroceanu; P Mickey Williams; Zora Modrusan; Burt G Feuerstein; Ken Aldape
Journal:  Cancer Cell       Date:  2006-03       Impact factor: 31.743

Review 9.  Targeting adaptive glioblastoma: an overview of proliferation and invasion.

Authors:  Qian Xie; Sandeep Mittal; Michael E Berens
Journal:  Neuro Oncol       Date:  2014-07-30       Impact factor: 12.300

Review 10.  The extracellular matrix: a dynamic niche in cancer progression.

Authors:  Pengfei Lu; Valerie M Weaver; Zena Werb
Journal:  J Cell Biol       Date:  2012-02-20       Impact factor: 10.539
  10 in total
  1 in total

Review 1.  The multifaceted mechanisms of malignant glioblastoma progression and clinical implications.

Authors:  Rui Sun; Albert H Kim
Journal:  Cancer Metastasis Rev       Date:  2022-08-03       Impact factor: 9.237
  1 in total

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