Literature DB >> 28780936

NAD+ Deficits in Age-Related Diseases and Cancer.

Amanda Garrido1, Nabil Djouder2.   

Abstract

The phenomenon of aging has gained widespread attention in recent times. Although significant advances have been made to better understand aging and its related pathologies including cancer, there is not yet a clear mechanism explaining why diseases and cancer are inherent parts of the aging process. Finding a unifying equation that could bridge aging and its related diseases would allow therapeutic development and solve an immense human health problem to live longer and better. In this review, we discuss NAD+ reduction as the central mechanism that may connect aging to its related pathologies and cancer. NAD+ boosters would ensure and ameliorate health quality during aging.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  L-tryptophan/kynurenine pathway; age-related diseases; aging; cancer; de novo NAD(+) synthesis; nicotinamide; nicotinamide mononucleotide; nicotinamide riboside

Mesh：

Substances：

Year:  2017        PMID： 28780936     DOI： 10.1016/j.trecan.2017.06.001

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  18 in total

Review 1.  Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses.

Authors:  Joshua E Lewis; Naveen Singh; Reetta J Holmila; Baran D Sumer; Noelle S Williams; Cristina M Furdui; Melissa L Kemp; David A Boothman
Journal:  Semin Radiat Oncol       Date:  2019-01       Impact factor: 5.934

Review 2.  The chemistry of the vitamin B3 metabolome.

Authors:  Mikhail V Makarov; Samuel A J Trammell; Marie E Migaud
Journal:  Biochem Soc Trans       Date:  2018-12-17       Impact factor: 5.407

3.  Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis.

Authors:  Cécile Cros; Marielle Margier; Hélène Cannelle; Julie Charmetant; Nicolas Hulo; Laurent Laganier; Alessia Grozio; Matthias Canault
Journal:  Front Mol Biosci       Date:  2022-06-27

Review 4.  NAD+-mediated regulation of mammalian base excision repair.

Authors:  Kate M Saville; Jennifer Clark; Anna Wilk; Gresyn D Rogers; Joel F Andrews; Christopher A Koczor; Robert W Sobol
Journal:  DNA Repair (Amst)       Date:  2020-09

5.  Single-Voxel 1 H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+ ) in humans at 7T using a 32-channel volume coil.

Authors:  Puneet Bagga; Hari Hariharan; Neil E Wilson; Joanne C Beer; Russell T Shinohara; Mark A Elliott; Joseph A Baur; Francesco M Marincola; Walter R Witschey; Mohammad Haris; John A Detre; Ravinder Reddy
Journal:  Magn Reson Med       Date:  2019-09-10       Impact factor: 4.668

6.  Nicotinamide riboside-amino acid conjugates that are stable to purine nucleoside phosphorylase.

Authors:  Faisal Hayat; Marie E Migaud
Journal:  Org Biomol Chem       Date:  2020-04-15       Impact factor: 3.876

7.  Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments.

Authors:  Ki Hyun Yoo; Jason J Tang; Mohammad Abdur Rashid; Chang Hoon Cho; Ana Corujo-Ramirez; Jonghoon Choi; Mun Gyeong Bae; Danielle Brogren; John R Hawse; Xiaonan Hou; S John Weroha; Alfredo Oliveros; Lindsey A Kirkeby; Joseph A Baur; Mi-Hyeon Jang
Journal:  Cancer Res       Date:  2021-03-26       Impact factor: 12.701

Review 8.  Gut microbiota changes in the extreme decades of human life: a focus on centenarians.

Authors:  Aurelia Santoro; Rita Ostan; Marco Candela; Elena Biagi; Patrizia Brigidi; Miriam Capri; Claudio Franceschi
Journal:  Cell Mol Life Sci       Date:  2017-10-14       Impact factor: 9.261

9.  Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency.

Authors:  Bo H Jonsson
Journal:  Nutrients       Date:  2018-01-27       Impact factor: 5.717

10.  Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation.

Authors:  Elisabet Cuyàs; Sara Verdura; Laura Llorach-Parés; Salvador Fernández-Arroyo; Jorge Joven; Begoña Martin-Castillo; Joaquim Bosch-Barrera; Joan Brunet; Alfons Nonell-Canals; Melchor Sanchez-Martinez; Javier A Menendez
Journal:  Front Endocrinol (Lausanne)       Date:  2018-11-06       Impact factor: 5.555
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