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Literature DB >> 28780930

Repurposing Drugs in Oncology: Next Steps.

Ciska Verbaanderd¹, Lydie Meheus², Isabelle Huys³, Pan Pantziarka⁴.

Abstract

The repurposing of existing non-cancer drugs is a potential source of new treatment options for cancer patients with high unmet medical needs. While scientific research is progressing rapidly in the field of drug repurposing, the implementation of drug repurposing still faces important financial and regulatory hurdles that should be addressed to optimise clinical adoption.

Entities: Disease Species

Keywords: drug repositioning; drug repurposing; health systems; neoplasms; policy

Mesh：

Substances：

Year: 2017 PMID： 28780930 DOI： 10.1016/j.trecan.2017.06.007

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

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Cited

18 in total

1. Computational design of PD-L1 small molecule inhibitors for cancer therapy.

Authors: Jaikanth Chandrasekaran; Senthilkumar Elumalai; Vidya Murugesan; Selvaraj Kunjiappan; Parasuraman Pavadai; Panneerselvam Theivendren
Journal: Mol Divers Date: 2022-08-25 Impact factor: 3.364

Review 2. Repurposing Infectious Diseases Vaccines Against Cancer.

Authors: Liese Vandeborne; Pan Pantziarka; An M T Van Nuffel; Gauthier Bouche
Journal: Front Oncol Date: 2021-05-13 Impact factor: 6.244

Review 3. Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target.

Authors: Saiful Islam; Shudong Wang; Nikola Bowden; Jennifer Martin; Richard Head
Journal: Br J Clin Pharmacol Date: 2021-07-09 Impact factor: 3.716

Review 4. Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.

Authors: J Javier Hernandez; Michael Pryszlak; Lindsay Smith; Connor Yanchus; Naheed Kurji; Vijay M Shahani; Steven V Molinski
Journal: Front Oncol Date: 2017-11-14 Impact factor: 6.244

Review 5. Drug Repurposing for the Treatment of Acute Myeloid Leukemia.

Authors: Vibeke Andresen; Bjørn T Gjertsen
Journal: Front Med (Lausanne) Date: 2017-11-29

6. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway.

Authors: Xin Wang; Xingye Wu; Zhonglin Zhang; Chao Ma; Tingting Wu; Shengli Tang; Zongyue Zeng; Shifeng Huang; Cheng Gong; Chengfu Yuan; Linghuan Zhang; Yixiao Feng; Bo Huang; Wei Liu; Bo Zhang; Yi Shen; Wenping Luo; Xi Wang; Bo Liu; Yan Lei; Zhenyu Ye; Ling Zhao; Daigui Cao; Lijuan Yang; Xian Chen; Rex C Haydon; Hue H Luu; Bing Peng; Xubao Liu; Tong-Chuan He
Journal: Sci Rep Date: 2018-12-17 Impact factor: 4.379

Repurposing Drugs in Oncology: Next Steps.

1. Computational design of PD-L1 small molecule inhibitors for cancer therapy.

Review 2. Repurposing Infectious Diseases Vaccines Against Cancer.

Review 3. Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target.

Review 4. Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.

Review 5. Drug Repurposing for the Treatment of Acute Myeloid Leukemia.

6. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway.

7. Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations.

Review 8. Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin.

Review 9. The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer.

Review 10. Receptor tyrosine kinase targeting in glioblastoma: performance, limitations and future approaches.