| Literature DB >> 28780739 |
Anis Chaari1, Alaa Sayed Mohamed2, Karim Abdelhakim2, Vipin Kauts2, William Francis Casey2.
Abstract
Background The onset of early and/or late seizures in brain injured patients is associated with worse outcome. So far, phenytoin is the most commonly used antiepileptic drug to prevent seizures in this group of patients. Objective In the current metaanalysis, we aimed to compare the efficacy and safety of phenytoin versus levetiracetam for seizure prophylaxis in brain injured patients. Methods A systematic search was conducted in PubMed and Cochrane Library Database by 2 investigators. Four randomized controlled trials (RCTs) were included (295 patients). Data were extracted and the quality of each RCT was assessed. Results Levetiracetam was found to be more effective than phenytoin in seizure prophylaxis (OR = 0.23; CI 95% [0.09-0.56]; Q test p value = 0.18 and I2 = 38%). A trend toward less serious side effects was also found in patients treated with levetiracetam (OR = 0.27; CI 95% [0.07-1.07]; Q test p value = 0.72 and I2 = 0%). Conclusion Levetiracetam is more effective and safer than phenytoin for seizure prophylaxis in brain injured patients.Entities:
Keywords: Efficacy; Levetiracetam; Phenytoin, Prophylaxis; Seizure; Side effects
Mesh：
Substances：
Year: 2017 PMID： 28780739 DOI： 10.1007/s11096-017-0507-6
Source DB: PubMed Journal: Int J Clin Pharm