| Literature DB >> 28780415 |
Tao Wang1, Caie Wu2, Gongjian Fan3, Tingting Li3, Hao Gong4, Fuliang Cao5.
Abstract
Ginkgo as a promising edible material and herbal medicine has received much attention due to its abundant starch contents and functional ingredient ginkgo biloba extracts (GBEs). Many foreign scholars suggest that GBEs can effectively ameliorate the symptoms of mild memory impairment and Alzheimer's dementia. However, an insurmountable problem with application of the GBEs is its low bioavailability, which restricts its application in vivo. Considering the biocompatibility between GBEs and starch, we have prepared ginkgo and corn starch-based nano-carriers, and thereby loaded GBEs onto starch nano-spheres (SNPs) by nanoprecipitation. Compared with unloaded SNPs (201-250nm), the mean sizes of the monodispersed and spherical GBEs-loaded SNPs were 255-396nm. Moreover, the loading amounts of GBEs onto ginkgo, and corn SNPs were 0.661-1.045, and 0.560mg/mg, respectively. In addition, in artificial gastric and intestinal juices, the GBEs-loaded SNPs exhibited a better sustained release than free GBEs.Entities:
Keywords: Ginkgo biloba extracts; Loading amount; Starch nano-carrier; Sustained release
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Year: 2017 PMID： 28780415 DOI： 10.1016/j.ijbiomac.2017.08.012
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953