Y Zhang1, A L Wagner2, X Wang1, B F Carlson3, Y Ding1, J P Montgomery3, B W Gillespie4, M L Boulton5. 1. Tianjin Centers for Disease Control and Prevention, Tianjin, China. 2. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Electronic address: awag@umich.edu. 3. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. 4. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. 5. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Abstract
OBJECTIVES: Infants aged <8 months are ineligible for measles vaccination in China but represent a disproportionate number of cases. We examined the risk factors for measles among infants in Tianjin, China. STUDY DESIGN: Case-control study. METHODS: Cases were enrolled from a surveillance system, and IgG-negative controls were sampled from registries at immunization clinics. A logistic regression model assessed for risk factors. RESULTS: Among 82 cases and 485 controls, exposure to a municipal hospital (OR [odds ratio]: 5.21; 95% confidence interval [CI]: 1.19-22.82) or a specialty hospital (OR: 13.22; 95% CI: 6.13-28.51) was associated with the disease, whereas visiting a township or district hospitals was not associated with increased odds of measles. CONCLUSIONS: Hospitals were an important focal point of measles transmission for infants. Hospitals, particularly higher-level municipal and specialty hospitals, should enforce infection control programs to separate infants with highly communicable diseases to prevent transmission.
OBJECTIVES:Infants aged <8 months are ineligible for measles vaccination in China but represent a disproportionate number of cases. We examined the risk factors for measles among infants in Tianjin, China. STUDY DESIGN: Case-control study. METHODS: Cases were enrolled from a surveillance system, and IgG-negative controls were sampled from registries at immunization clinics. A logistic regression model assessed for risk factors. RESULTS: Among 82 cases and 485 controls, exposure to a municipal hospital (OR [odds ratio]: 5.21; 95% confidence interval [CI]: 1.19-22.82) or a specialty hospital (OR: 13.22; 95% CI: 6.13-28.51) was associated with the disease, whereas visiting a township or district hospitals was not associated with increased odds of measles. CONCLUSIONS: Hospitals were an important focal point of measles transmission for infants. Hospitals, particularly higher-level municipal and specialty hospitals, should enforce infection control programs to separate infants with highly communicable diseases to prevent transmission.
Authors: Matthew L Boulton; Xiexiu Wang; Ying Zhang; JoLynn P Montgomery; Abram L Wagner; Bradley F Carlson; Yaxing Ding; Xiaoyan Li; Brenda Gillespie; Xu Su Journal: Vaccine Date: 2016-05-03 Impact factor: 3.641
Authors: Cara Bess Janusz; Abram L Wagner; Nina B Masters; Yaxing Ding; Ying Zhang; David W Hutton; Matthew L Boulton Journal: Vaccine Date: 2020-05-22 Impact factor: 3.641
Authors: Matthew L Boulton; Xiexiu Wang; Abram L Wagner; Ying Zhang; Bradley F Carlson; Brenda W Gillespie; Yaxing Ding Journal: J Infect Dis Date: 2017-11-27 Impact factor: 5.226
Authors: Xu Su; Bradley F Carlson; Xiexiu Wang; Xiaoyan Li; Ying Zhang; JoLynn P Montgomery; Yaxing Ding; Abram L Wagner; Brenda Gillespie; Matthew L Boulton Journal: J Infect Public Health Date: 2017-09-28 Impact factor: 3.718