Literature DB >> 28780002

Sex-Specific Gene Expression and Life Span Regulation.

John Tower1.   

Abstract

Aging-related diseases show a marked sex bias. For example, women live longer than men yet have more Alzheimer's disease and osteoporosis, whereas men have more cancer and Parkinson's disease. Understanding the role of sex will be important in designing interventions and in understanding basic aging mechanisms. Aging also shows sex differences in model organisms. Dietary restriction (DR), reduced insulin/IGF1-like signaling (IIS), and reduced TOR signaling each increase life span preferentially in females in both flies and mice. Maternal transmission of mitochondria to offspring may lead to greater control over mitochondrial functions in females, including greater life span and a larger response to diet. Consistent with this idea, males show greater loss of mitochondrial gene expression with age.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Strehler–Mildvan; X chromosome; aging; dosage compensation; mitochondria; sex

Mesh：

Year:  2017        PMID： 28780002      PMCID： PMC5667568          DOI： 10.1016/j.tem.2017.07.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  82 in total

1.  Comparative and meta-analytic insights into life extension via dietary restriction.

Authors:  Shinichi Nakagawa; Malgorzata Lagisz; Katie L Hector; Hamish G Spencer
Journal:  Aging Cell       Date:  2012-02-22       Impact factor: 9.304

Review 2.  Escape Artists of the X Chromosome.

Authors:  Bradley P Balaton; Carolyn J Brown
Journal:  Trends Genet       Date:  2016-04-18       Impact factor: 11.639

3.  Molecular antagonism between X-chromosome and autosome signals determines nematode sex.

Authors:  Behnom Farboud; Paola Nix; Margaret M Jow; John M Gladden; Barbara J Meyer
Journal:  Genes Dev       Date:  2013-05-10       Impact factor: 11.361

4.  Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.

Authors:  Konstantinos Palikaras; Eirini Lionaki; Nektarios Tavernarakis
Journal:  Nature       Date:  2015-04-20       Impact factor: 49.962

Review 5.  Sex-specific regulation of aging and apoptosis.

Authors:  John Tower
Journal:  Mech Ageing Dev       Date:  2006-06-09       Impact factor: 5.432

6.  The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.

Authors:  Louis R Lapierre; C Daniel De Magalhaes Filho; Philip R McQuary; Chu-Chiao Chu; Orane Visvikis; Jessica T Chang; Sara Gelino; Binnan Ong; Andrew E Davis; Javier E Irazoqui; Andrew Dillin; Malene Hansen
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

7.  A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.

Authors:  Bryan G Hughes; Siegfried Hekimi
Journal:  PLoS One       Date:  2011-10-10       Impact factor: 3.240

8.  Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster.

Authors:  Tapiwanashe Magwere; Tracey Chapman; Linda Partridge
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-01       Impact factor: 6.053

9.  Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender.

Authors:  Xiangru Xu; Ming Zhan; Wenzhen Duan; Vinayakumar Prabhu; Randall Brenneman; William Wood; Jeff Firman; Huai Li; Peisu Zhang; Carol Ibe; Alan B Zonderman; Dan L Longo; Suresh Poosala; Kevin G Becker; Mark P Mattson
Journal:  Genome Biol       Date:  2007       Impact factor: 13.583

10.  Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration.

Authors:  Ran Lin; Alessia Angelin; Federico Da Settimo; Claudia Martini; Sabrina Taliani; Shigong Zhu; Douglas C Wallace
Journal:  Aging Cell       Date:  2014-06       Impact factor: 9.304
View more
  42 in total

1.  A characterization of cis- and trans-heritability of RNA-Seq-based gene expression.

Authors:  Klaasjan G Ouwens; Rick Jansen; Michel G Nivard; Jenny van Dongen; Maia J Frieser; Jouke-Jan Hottenga; Wibowo Arindrarto; Annique Claringbould; Maarten van Iterson; Hailiang Mei; Lude Franke; Bastiaan T Heijmans; Peter A C 't Hoen; Joyce van Meurs; Andrew I Brooks; Brenda W J H Penninx; Dorret I Boomsma
Journal:  Eur J Hum Genet       Date:  2019-09-26       Impact factor: 4.246

2.  Boolean gene regulatory network model of centromere function in Saccharomyces cerevisiae.

Authors:  Emir Haliki; Nursen Alpagut Keskin; Ozgur Masalci
Journal:  J Biol Phys       Date:  2019-06-07       Impact factor: 1.365

3.  Drosophila Flies in the Face of Aging.

Authors:  John Tower
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2019-09-15       Impact factor: 6.053

Review 4.  Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare.

Authors:  Davide Cirillo; Silvina Catuara-Solarz; Czuee Morey; Emre Guney; Laia Subirats; Simona Mellino; Annalisa Gigante; Alfonso Valencia; María José Rementeria; Antonella Santuccione Chadha; Nikolaos Mavridis
Journal:  NPJ Digit Med       Date:  2020-06-01

5.  Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.

Authors:  Helen B Foley; Patrick Y Sun; Rocio Ramirez; Brandon K So; Yaamini R Venkataraman; Emily N Nixon; Kelvin J A Davies; Suzanne Edmands
Journal:  Exp Gerontol       Date:  2019-02-07       Impact factor: 4.032

6.  Mitochondrial-Y chromosome epistasis in Drosophila melanogaster.

Authors:  J Arvid Ågren; Manisha Munasinghe; Andrew G Clark
Journal:  Proc Biol Sci       Date:  2020-10-21       Impact factor: 5.349

7.  Effects of oxidative stress on sex-specific gene expression in the copepod Tigriopus californicus revealed by single individual RNA-seq.

Authors:  Ning Li; Natasha Arief; Suzanne Edmands
Journal:  Comp Biochem Physiol Part D Genomics Proteomics       Date:  2019-07-11       Impact factor: 2.674

8.  Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD).

Authors:  Christina Kiel; Tobias Strunz; Felix Grassmann; Bernhard H F Weber
Journal:  Cells       Date:  2020-10-08       Impact factor: 6.600

9.  Gut microbiota remodeling reverses aging-associated inflammation and dysregulation of systemic bile acid homeostasis in mice sex-specifically.

Authors:  Junli Ma; Ying Hong; Ningning Zheng; Guoxiang Xie; Yuanzhi Lyu; Yu Gu; Chuchu Xi; Linlin Chen; Gaosong Wu; Yue Li; Xin Tao; Jing Zhong; Zhenzhen Huang; Wenbin Wu; Lin Yuan; Min Lin; Xiong Lu; Weidong Zhang; Wei Jia; Lili Sheng; Houkai Li
Journal:  Gut Microbes       Date:  2020-06-09

Review 10.  Sex differences and the neurobiology of affective disorders.

Authors:  David R Rubinow; Peter J Schmidt
Journal:  Neuropsychopharmacology       Date:  2018-07-09       Impact factor: 7.853
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.