Hakan Yılmaz1, Özlem Yılmaz2, İlkay Çamlıdağ3,4, Ümit Belet5, Hüseyin Akan5. 1. Department of Radiology, Hitit University, Çorum Training and Research Hospital, Çorum, Turkey. 2. Department of Dermatology, Hitit University, Çorum Training and Research Hospital, 19200, Çorum, Turkey. 3. Department of Radiology, Ondokuz Mayıs University, 55139, Kurupelit/Samsun, Turkey. ilkayozaydin@hotmail.com. 4. , Cumhuriyet M., Adnan Menderes Bulv., Zeren Sitesi, C Blok Kat:4 No:8, 55200, Atakum/Samsun, Turkey. ilkayozaydin@hotmail.com. 5. Department of Radiology, Ondokuz Mayıs University, 55139, Kurupelit/Samsun, Turkey.
Abstract
PURPOSE: The purpose of our study was to evaluate the efficacy of percutaneous sclerotherapy using bleomycin in treatment of lymphatic malformations. METHODS: Between January 2009 and January 2013, ten patients with lymphatic malformations who were admitted to the interventional radiology department were included in this retrospective study. Intralesional bleomycin was administered by percutaneous injection through 21-23 Gauge needles with a dose of 1 mg/kg body weight. Patients were clinically and radiologically assessed at baseline and followed at first and third months after treatment. Response to treatment was measured visually by using photographs and by radiological images. Symptomatic improvement was also evaluated either by patients or parents. RESULTS: Excellent resolution was obtained visually in 80% of patients with lymphatic malformation. Significant resolution was achieved in 20% of patients. The percentage of radiographic resolution in size and the improvement in symptoms evaluated by patients or parents were similar with visual outcomes. No side effects were recorded except for fever in one patient and transient erythema in another patient. CONCLUSION: Intralesional bleomycin is a safe and effective treatment for patients with lymphatic malformations.
PURPOSE: The purpose of our study was to evaluate the efficacy of percutaneous sclerotherapy using bleomycin in treatment of lymphatic malformations. METHODS: Between January 2009 and January 2013, ten patients with lymphatic malformations who were admitted to the interventional radiology department were included in this retrospective study. Intralesional bleomycin was administered by percutaneous injection through 21-23 Gauge needles with a dose of 1 mg/kg body weight. Patients were clinically and radiologically assessed at baseline and followed at first and third months after treatment. Response to treatment was measured visually by using photographs and by radiological images. Symptomatic improvement was also evaluated either by patients or parents. RESULTS: Excellent resolution was obtained visually in 80% of patients with lymphatic malformation. Significant resolution was achieved in 20% of patients. The percentage of radiographic resolution in size and the improvement in symptoms evaluated by patients or parents were similar with visual outcomes. No side effects were recorded except for fever in one patient and transient erythema in another patient. CONCLUSION: Intralesional bleomycin is a safe and effective treatment for patients with lymphatic malformations.
Authors: Patricia E Burrows; Ragheed K Mitri; Ahmad Alomari; Horacio M Padua; David J Lord; Mary Beth Sylvia; Steven J Fishman; John B Mulliken Journal: Lymphat Res Biol Date: 2008 Impact factor: 2.589
Authors: Frédérique C M Bouwman; Silje S Kooijman; Bas H Verhoeven; Leo J Schultze Kool; Carine J M van der Vleuten; Sanne M B I Botden; Ivo de Blaauw Journal: Eur J Pediatr Date: 2020-10-13 Impact factor: 3.183