Literature DB >> 2877940

Beta-globin gene polymorphism in Saudis--triple Hpa I fragments.

M A el-Hazmi, F A Jabbar, A R Al-Swailem, A S Warsy.   

Abstract

In an attempt to investigate beta-globin gene polymorphism in the Saudi population, DNA samples were analysed using restriction endonucleases, Mst II and Hpa I. Both beta A and beta S genes showed extensive polymorphism and were found to be linked to 13.0 kb, 7.6 kb, 7.0 kb, and 5.6 kb Hpa I fragments. Three DNA samples out of a total of 436 analysed, had beta-globin gene linked to three Hpa I fragments of the sizes 13.0 kb, 7.6 kb, and 5.6 kb. In this paper we present our findings and discuss the possibility of multiple beta-globin loci.

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Year:  1986        PMID： 2877940     DOI： 10.1007/bf00282555

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

1.  Estimation of small percentages of foetal haemoglobin.

Authors:  K BETKE; H R MARTI; I SCHLICHT
Journal:  Nature       Date:  1959-12-12       Impact factor: 49.962

2.  A new technique for differentiation of hemoglobin.

Authors:  A R ROBINSON; M ROBSON; A P HARRISON; W W ZUELZER
Journal:  J Lab Clin Med       Date:  1957-11

3.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

4.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

5.  Heterogeneity of DNA fragments associated with the sickle-globin gene.

Authors:  J Feldenzer; J G Mears; A L Burns; C Natta; A Bank
Journal:  J Clin Invest       Date:  1979-09       Impact factor: 14.808

Review 6.  DNA polymorphism and molecular pathology of the human globin gene clusters.

Authors:  S E Antonarakis; H H Kazazian; S H Orkin
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

7.  Sickle gene. Its origin and diffusion from West Africa.

Authors:  J G Mears; H M Lachman; R Cabannes; K P Amegnizin; D Labie; R L Nagel
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

8.  A new triplicated alpha-globin gene arrangement in man.

Authors:  R J Trent; D R Higgs; J B Clegg; D J Weatherall
Journal:  Br J Haematol       Date:  1981-09       Impact factor: 6.998

9.  Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

Authors:  Y W Kan; A M Dozy
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

10.  Beta-globin gene polymorphism in the Saudi Arab population.

Authors:  M A el-Hazmi
Journal:  Hum Genet       Date:  1986-05       Impact factor: 4.132
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