Hyunah Kim1, Hyunyong Lee2, Hyeon Woo Yim3, Hun-Sung Kim4. 1. College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea. 2. Clinical Research Coordinating Center, Catholic Medical Center, The Catholic University of Korea, Seoul, Republic of Korea. 3. Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 4. Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Republic of Korea. Electronic address: 01cadiz@hanmail.net.
Abstract
AIMS: Vitamin D is associated with diabetes mellitus (DM) occurrence by affecting insulin secretion and resistance. However, variations exist due to differences in vitamin D sensitivity among individuals. We investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] status and various indices of DM in a Korean population without DM. METHODS: Large-scaled population-based analysis was conducted from the Korea National Health and Nutrition Examination Survey data (2010-2012) were analyzed. Adult survey participants >20years without diabetes (n=15,169) were included. RESULTS: The mean 25(OH)D levels were lower in females, subjects aged 20-39 years, and subjects with body mass index <21.1kg/m2 and less physical activity (p<0.001). Further, the mean 25(OH)D levels tended to be lower in subjects with FBG >126mg/dL. After adjustment for potential confounders, 25(OH)D was not correlated with FBG (p=0.925) or HbA1c (p=0.336); however, fasting insulin (β=-0.072, p=0.011) and homeostasis model assessment of β-cell function (β=-0.007, p<0.001) showed significant negative correlations with 25(OH)D levels. CONCLUSION: Although 25(OH)D status was not significantly associated with FBG or HbA1c, low 25(OH)D levels were associated with compensative insulin increase and ongoing increase in insulin resistance. Thus, vitamin D deficiency is assumed to influence DM occurrence.
AIMS: Vitamin D is associated with diabetes mellitus (DM) occurrence by affecting insulin secretion and resistance. However, variations exist due to differences in vitamin D sensitivity among individuals. We investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] status and various indices of DM in a Korean population without DM. METHODS: Large-scaled population-based analysis was conducted from the Korea National Health and Nutrition Examination Survey data (2010-2012) were analyzed. Adult survey participants >20years without diabetes (n=15,169) were included. RESULTS: The mean 25(OH)D levels were lower in females, subjects aged 20-39 years, and subjects with body mass index <21.1kg/m2 and less physical activity (p<0.001). Further, the mean 25(OH)D levels tended to be lower in subjects with FBG >126mg/dL. After adjustment for potential confounders, 25(OH)D was not correlated with FBG (p=0.925) or HbA1c (p=0.336); however, fasting insulin (β=-0.072, p=0.011) and homeostasis model assessment of β-cell function (β=-0.007, p<0.001) showed significant negative correlations with 25(OH)D levels. CONCLUSION: Although 25(OH)D status was not significantly associated with FBG or HbA1c, low 25(OH)D levels were associated with compensative insulin increase and ongoing increase in insulin resistance. Thus, vitamin D deficiency is assumed to influence DM occurrence.