| Literature DB >> 28778450 |
Mahesh M Kumar1, Manjunatha M Venkataswamy1, Gopinath Sathyanarayanan2, Harish Thippeswamy2, Prabha S Chandra2, Reeta S Mani3.
Abstract
Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T cells, while activated CD8 and memory regulatory T cells (Tregs) were increased in women with PP as against healthy controls. The CD14-CD16+non-classical monocytes, CD11c+myeloid DCs and cytotoxic CD56dimCD16+ were reduced, while CD56brtCD16+/-regulatory NK cells were elevated in women with PP. The variations in immune cell subsets highlight the generalized immune dysregulation in PP.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28778450 DOI： 10.1016/j.jneuroim.2017.06.002
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478