Literature DB >> 28778441

Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease.

E Caggiu1, K Paulus2, G Galleri2, G Arru2, R Manetti2, G P Sechi2, L A Sechi3.   

Abstract

Environmental factors are implicated in the development of Parkinson's disease (PD). The aim of this study is to investigate the role of cell-mediated immunity upon a specific immune-stimulation with HSV-1 and human alpha-synuclein homologues peptides by using the intracellular cytokine method on Parkinson's patients and healthy controls. The study showed, for the first time, a specific response to TNF-α CD8, CD4 and NK cells after stimulation in PD patients. Our data show a possible role of the immune system in the pathogenesis of Parkinson's disease, and that HSV-1 infections may lead to a progression of the disease.
Copyright © 2017. Published by Elsevier B.V.

Entities:  

Keywords:  Autoimmunity; HSV1; Molecular mimicry; Parkinson's disease; Peptides

Mesh：

Substances：

Year:  2017        PMID： 28778441     DOI： 10.1016/j.jneuroim.2017.06.004

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  19 in total

Review 1.  Immune system responses in Parkinson's disease: Early and dynamic.

Authors:  Malú G Tansey; Marina Romero-Ramos
Journal:  Eur J Neurosci       Date:  2018-12-10       Impact factor: 3.386

Review 2.  Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.

Authors:  Cecilia S Lindestam Arlehamn; Francesca Garretti; David Sulzer; Alessandro Sette
Journal:  Curr Opin Immunol       Date:  2019-08-17       Impact factor: 7.486

Review 3.  GBA1 and The Immune System: A Potential Role in Parkinson's Disease?

Authors:  Zaid A M Al-Azzawi; Saman Arfaie; Ziv Gan-Or
Journal:  J Parkinsons Dis       Date:  2022       Impact factor: 5.520

4.  Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson's disease.

Authors:  Congcong Sun; Zhenxiang Zhao; Wenfei Yu; Mingshu Mo; Chengyuan Song; Youfeng Si; Yiming Liu
Journal:  Ann Transl Med       Date:  2019-11

5.  Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor.

Authors:  Daniella Iglesias-Hernandez; Silvia Chapman; Keith Radler; Hollie Dowd; Edward D Huey; Stephanie Cosentino; Elan D Louis
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2021-05-11

6.  Abnormalities of age-related T cell senescence in Parkinson's disease.

Authors:  C H Williams-Gray; R S Wijeyekoon; K M Scott; S Hayat; R A Barker; J L Jones
Journal:  J Neuroinflammation       Date:  2018-05-28       Impact factor: 8.322

Review 7.  T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease.

Authors:  Javier Campos-Acuña; Daniela Elgueta; Rodrigo Pacheco
Journal:  Front Immunol       Date:  2019-02-15       Impact factor: 7.561

Review 8.  Inflammation, Infectious Triggers, and Parkinson's Disease.

Authors:  Elisa Caggiu; Giannina Arru; Sepideh Hosseini; Magdalena Niegowska; GianPietro Sechi; Ignazio Roberto Zarbo; Leonardo A Sechi
Journal:  Front Neurol       Date:  2019-02-19       Impact factor: 4.003

9.  Herpes simplex virus-1 (HSV-1) infection induces a potent but ineffective IFN-λ production in immune cells of AD and PD patients.

Authors:  Francesca La Rosa; Simone Agostini; Anna Bianchi; Raffaello Nemni; Federica Piancone; Ivana Marventano; Roberta Mancuso; Marina Saresella; Mario Clerici
Journal:  J Transl Med       Date:  2019-08-27       Impact factor: 5.531

Review 10.  Alpha synuclein in hematopoiesis and immunity.

Authors:  Yu Pei; Robert W Maitta
Journal:  Heliyon       Date:  2019-10-18
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