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Literature DB >> 28778433

Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes.

Abstract

Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with lysophosphatidylcholine (LPC), a proinflammatory lipid generated under pathological conditions in the brain. LPC-induced caspase-1 activation in microglia was found to depend on LPS prestimulation, inflammasome NLRP3 and adaptor molecule ASC. Furthermore, knockdown of inflammasome NLRC4 inhibited LPC-stimulated caspase-1 activity in microglia, suggesting the requirement of two inflammasomes for optimal caspase-1 activity.

Entities: Chemical Gene

Keywords: Caspase-1; Inflammasome; Lysophospholipids; Microglia

Mesh：

Substances：

Year: 2017 PMID： 28778433 DOI： 10.1016/j.jneuroim.2017.07.004

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

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Cited

13 in total

1. Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages.

Authors: Yongeun Kim; Anthony D Gromovsky; J Mark Brown; Soonkyu Chung
Journal: J Nutr Biochem Date: 2018-06-04 Impact factor: 6.048

Review 2. Glial Cells and Brain Diseases: Inflammasomes as Relevant Pathological Entities.

Authors: Esperanza Mata-Martínez; Mauricio Díaz-Muñoz; Francisco G Vázquez-Cuevas
Journal: Front Cell Neurosci Date: 2022-06-16 Impact factor: 6.147

3. Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts.

Authors: Hui-Ching Tseng; Chih-Chung Lin; Chen-Yu Wang; Chien-Chung Yang; Li-Der Hsiao; Chuen-Mao Yang
Journal: Cell Mol Life Sci Date: 2018-09-18 Impact factor: 9.261

4. Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats.

Authors: Pardes Habib; Julie Harms; Adib Zendedel; Cordian Beyer; Alexander Slowik
Journal: Int J Mol Sci Date: 2020-07-07 Impact factor: 5.923

5. Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

Authors: Song-Yang Zhang; Yong-Qiang Dong; Pengcheng Wang; Xingzhong Zhang; Yu Yan; Lulu Sun; Bo Liu; Dafang Zhang; Heng Zhang; Huiying Liu; Wei Kong; Gang Hu; Yatrik M Shah; Frank J Gonzalez; Xian Wang; Changtao Jiang
Journal: EBioMedicine Date: 2018-04-27 Impact factor: 8.143

6. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.

Authors: Cesar Rivas-Santiago; Irma González-Curiel; Sergio Zarazua; Michael Murgu; Alonso Ruiz Cardona; Blanca Lazalde; Edgar E Lara-Ramírez; Edgar Vázquez; Julio Enrique Castañeda-Delgado; Bruno Rivas-Santiago; Jesús Adrián Lopez; Alberto R Cervantes-Villagrana; Yamilé López-Hernández
Journal: Biomed Res Int Date: 2019-10-15 Impact factor: 3.411

7. Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells.

Authors: Rafael Corrêa; Luís Felipe Fonseca Silva; Dalila Juliana Silva Ribeiro; Raquel das Neves Almeida; Igor de Oliveira Santos; Luís Henrique Corrêa; Lívia Pimentel de Sant'Ana; Leonardo Santos Assunção; Patrícia T Bozza; Kelly Grace Magalhães
Journal: Front Immunol Date: 2020-01-09 Impact factor: 7.561