Rachid Mahmoudi1, Jean-Luc Novella2, Patrick Manckoundia3, Faiza Ahssaini4, Pierre-Olivier Lang5, François Blanchard2, Damien Jolly6, Moustapha Dramé6. 1. Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, F-51092, France; Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, F-51092, France. Electronic address: rmahmoudi@chu-reims.fr. 2. Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, F-51092, France; Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, F-51092, France. 3. Department of Geriatric Rehabilitation, Dijon University Hospitals, Champmaillot Hospital, Dijon, F-21079, France; Inserm/U1093 Cognition Action Plasticity, University of Burgundy Franche-Comté, Dijon, F-21078, France. 4. Department of Geriatrics and Internal Medicine, Reims University Hospitals, Maison Blanche Hospital, Reims, F-51092, France. 5. Medicine and Geriatric Rehabilitation Department, Lausanne University Hospitals, Lausanne, CH-1011, Switzerland. 6. Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne, Reims, F-51092, France; Department of Research and Public Health, Reims University Hospitals, Robert Debré Hospital, Reims, F-51092, France.
Abstract
OBJECTIVE: To investigate whether functional mobility is a predictor of 12-month mortality in elderly subjects with dementia. STUDY DESIGN: Prospective multicentre study performed in nine French university hospitals. Patients aged 75 years or more and hospitalised in medical wards via the emergency department were eligible. Those with a diagnosis of dementia were considered in the analyses. MAIN OUTCOME MEASURES: Patients' characteristics obtained through comprehensive geriatric assessment performed during the first week of hospitalisation. Functional mobility was assessed using the timed "Up & Go" test. The main outcome was time to death within the 12 months of follow-up. Bivariable relationships between each risk factor and mortality were assessed using a Cox regression model with one explanatory variable. For multivariable analysis, the Cox regression model was used in a stepwise method after examining potential confounders and interactions. RESULTS: In all, 589 patients had a diagnosis of dementia, and were considered in the present analyses. Their mean age was 86±6years and most (69%) were female. The prevalence of functional mobility disorders was 86%. After 12 months, 232 (39%) had died. After adjustment for potential confounders, functional mobility was associated with a significantly higher risk of 12-month mortality (HR=1.66; 95% CI=1.02-2.71; p=0.04). CONCLUSIONS: Impaired functional mobility as assessed by the timed Up & Go test identifies subjects with dementia at risk of unfavourable outcome.
OBJECTIVE: To investigate whether functional mobility is a predictor of 12-month mortality in elderly subjects with dementia. STUDY DESIGN: Prospective multicentre study performed in nine French university hospitals. Patients aged 75 years or more and hospitalised in medical wards via the emergency department were eligible. Those with a diagnosis of dementia were considered in the analyses. MAIN OUTCOME MEASURES: Patients' characteristics obtained through comprehensive geriatric assessment performed during the first week of hospitalisation. Functional mobility was assessed using the timed "Up & Go" test. The main outcome was time to death within the 12 months of follow-up. Bivariable relationships between each risk factor and mortality were assessed using a Cox regression model with one explanatory variable. For multivariable analysis, the Cox regression model was used in a stepwise method after examining potential confounders and interactions. RESULTS: In all, 589 patients had a diagnosis of dementia, and were considered in the present analyses. Their mean age was 86±6years and most (69%) were female. The prevalence of functional mobility disorders was 86%. After 12 months, 232 (39%) had died. After adjustment for potential confounders, functional mobility was associated with a significantly higher risk of 12-month mortality (HR=1.66; 95% CI=1.02-2.71; p=0.04). CONCLUSIONS: Impaired functional mobility as assessed by the timed Up & Go test identifies subjects with dementia at risk of unfavourable outcome.
Authors: Eftychia Kotronia; S Goya Wannamethee; A Olia Papacosta; Peter H Whincup; Lucy T Lennon; Marjolein Visser; Robert J Weyant; Tamara B Harris; Sheena E Ramsay Journal: J Am Med Dir Assoc Date: 2019-08-10 Impact factor: 4.669
Authors: Karen Van Ooteghem; Kristin E Musselman; Avril Mansfield; David Gold; Meghan N Marcil; Ron Keren; Maria Carmela Tartaglia; Alastair J Flint; Andrea Iaboni Journal: Alzheimers Dement (N Y) Date: 2019-08-31