Yung-Tsan Wu1, Tsung-Yen Ho2, Yu-Ching Chou3, Ming-Jen Ke2, Tsung-Ying Li1, Chia-Kuang Tsai4, Liang-Cheng Chen5. 1. Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, Republic of China; Integrated Pain Management Center, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, Republic of China. 2. Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, Republic of China. 3. School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China. 4. Department of Neurology, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, Republic of China; Graduate Institute of Medical Science, School of Medicine, Taipei, Taiwan, Republic of China. 5. Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, Republic of China. Electronic address: clctsgh@yahoo.com.tw.
Abstract
OBJECTIVE: To assess the 6-month effectiveness of ultrasound-guided perineural injection therapy (PIT) using 5% dextrose (D5W) in patients with mild-to-moderate carpal tunnel syndrome (CTS). PATIENTS AND METHODS: A prospective, randomized, placebo-controlled, and double-blind study was conducted between May 1, 2016, through March 30, 2017. A total of 49 participants diagnosed with mild-to-moderate CTS were randomized into D5W and control groups. Participants in the D5W group received 1 session of ultrasound-guided PIT with 5 cc of D5W, and the control group received PIT with normal saline. The visual analog scale measured pain as a primary outcome. Secondary outcomes were Boston Carpal Tunnel Syndrome Questionnaire scores, the cross-sectional area of the median nerve, and electrophysiological measurement results. Assessment was performed before injection and at 1, 3, and 6 months post-injection. RESULTS: All patients (data from 30 wrists in each group) completed the study. Compared with the control group, at all post-injection time points, the D5W group had a significant reduction in pain and disability, improvement on electrophysiological response measures, and decreased cross-sectional area of the median nerve. CONCLUSION: Our study reveals that ultrasound-guided PIT with D5W is an effective treatment for patients with mild-to-moderate CTS. TRIAL REGISTRATION: www.ClinicalTrials.gov: NCT02809261.
RCT Entities:
OBJECTIVE: To assess the 6-month effectiveness of ultrasound-guided perineural injection therapy (PIT) using 5% dextrose (D5W) in patients with mild-to-moderate carpal tunnel syndrome (CTS). PATIENTS AND METHODS: A prospective, randomized, placebo-controlled, and double-blind study was conducted between May 1, 2016, through March 30, 2017. A total of 49 participants diagnosed with mild-to-moderate CTS were randomized into D5W and control groups. Participants in the D5W group received 1 session of ultrasound-guided PIT with 5 cc of D5W, and the control group received PIT with normal saline. The visual analog scale measured pain as a primary outcome. Secondary outcomes were Boston Carpal Tunnel Syndrome Questionnaire scores, the cross-sectional area of the median nerve, and electrophysiological measurement results. Assessment was performed before injection and at 1, 3, and 6 months post-injection. RESULTS: All patients (data from 30 wrists in each group) completed the study. Compared with the control group, at all post-injection time points, the D5W group had a significant reduction in pain and disability, improvement on electrophysiological response measures, and decreased cross-sectional area of the median nerve. CONCLUSION: Our study reveals that ultrasound-guided PIT with D5W is an effective treatment for patients with mild-to-moderate CTS. TRIAL REGISTRATION: www.ClinicalTrials.gov: NCT02809261.
Authors: Ta-Chung Chao; Kenneth Dean Reeves; King Hei Stanley Lam; Tsung-Ying Li; Yung-Tsan Wu Journal: J Clin Med Date: 2022-06-27 Impact factor: 4.964
Authors: Mar Hernández-Secorún; Raquel Montaña-Cortés; César Hidalgo-García; Jacobo Rodríguez-Sanz; Jaime Corral-de-Toro; Sofia Monti-Ballano; Sami Hamam-Alcober; José Miguel Tricás-Moreno; María Orosia Lucha-López Journal: Int J Environ Res Public Health Date: 2021-02-28 Impact factor: 3.390