Literature DB >> 28777942

Combining hiPSCs and Human Genetics: Major Applications in Drug Development.

Jin Zhang1, Hu Li2, Alan Trounson3, Joseph C Wu4, Paul Nioi5.   

Abstract

Merging iPSC models and human genetic research has opened up new avenues in understanding disease mechanisms and target biology, which facilitate exciting translation of this research to many areas of drug development. We highlight recent applications of these combined disciplines and discuss remaining challenges and potential solutions.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28777942     DOI： 10.1016/j.stem.2017.07.012

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  5 in total

Review 1.  Mechanobiology Assays with Applications in Cardiomyocyte Biology and Cardiotoxicity.

Authors:  Cheavar A Blair; Beth L Pruitt
Journal:  Adv Healthc Mater       Date:  2020-04-09       Impact factor: 9.933

2.  Drug discovery in psychopharmacology: from 2D models to cerebral organoids
.

Authors:  Andrea Carlo Rossetti; Philipp Koch; Julia Ladewig
Journal:  Dialogues Clin Neurosci       Date:  2019       Impact factor: 5.986

3.  Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Authors:  Suet Nee Chen; Matthew R G Taylor; Luisa Mestroni
Journal:  Circ Genom Precis Med       Date:  2018-03

Review 4.  Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems.

Authors:  Florian J Raabe; Sabrina Galinski; Sergi Papiol; Peter G Falkai; Andrea Schmitt; Moritz J Rossner
Journal:  NPJ Schizophr       Date:  2018-11-19

Review 5.  Therapeutic Plasticity of Neural Stem Cells.

Authors:  Linda Ottoboni; Beatrice von Wunster; Gianvito Martino
Journal:  Front Neurol       Date:  2020-03-20       Impact factor: 4.003
  5 in total

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