Literature DB >> 28777566

Small-Molecule Modulation of Protein Homeostasis.

George M Burslem1, Craig M Crews1.   

Abstract

Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.

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Year:  2017        PMID： 28777566     DOI： 10.1021/acs.chemrev.7b00077

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


  67 in total

1.  Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

Authors:  Matthew G Costales; Blessy Suresh; Kamalakannan Vishnu; Matthew D Disney
Journal:  Cell Chem Biol       Date:  2019-05-23       Impact factor: 8.116

Review 2.  Preclinical and Clinical Advances of Targeted Protein Degradation as a Novel Cancer Therapeutic Strategy: An Oncologist Perspective.

Authors:  Xinrui Yang; He Yin; Richard D Kim; Jason B Fleming; Hao Xie
Journal:  Target Oncol       Date:  2020-12-28       Impact factor: 4.493

Review 3.  Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.

Authors:  Rachel J Harding; Yu-Feng Tong
Journal:  Acta Pharmacol Sin       Date:  2018-04-05       Impact factor: 6.150

Review 4.  Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Authors:  Donglu Zhang; Cornelis E C A Hop; Gabriela Patilea-Vrana; Gautham Gampa; Herana Kamal Seneviratne; Jashvant D Unadkat; Jane R Kenny; Karthik Nagapudi; Li Di; Lian Zhou; Mark Zak; Matthew R Wright; Namandjé N Bumpus; Richard Zang; Xingrong Liu; Yurong Lai; S Cyrus Khojasteh
Journal:  Drug Metab Dispos       Date:  2019-07-02       Impact factor: 3.922

5.  Emerging Cancer Therapeutic Targets in Protein Homeostasis.

Authors:  Prabhakar Bastola; Derek B Oien; Megan Cooley; Jeremy Chien
Journal:  AAPS J       Date:  2018-08-27       Impact factor: 4.009

6.  Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach.

Authors:  Chan-I Chung; Qiang Zhang; Xiaokun Shu
Journal:  Anal Chem       Date:  2018-11-30       Impact factor: 6.986

Review 7.  Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery.

Authors:  Marcus J C Long; Dziyana Hnedzko; Bo Kyoung Kim; Yimon Aye
Journal:  Chembiochem       Date:  2019-04-01       Impact factor: 3.164

8.  AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells.

Authors:  Charles H Wolstenholme; Hang Hu; Songtao Ye; Brian E Funk; Divya Jain; Chia-Heng Hsiung; Gang Ning; Yu Liu; Xiaosong Li; Xin Zhang
Journal:  J Am Chem Soc       Date:  2020-10-05       Impact factor: 15.419

9.  A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL.

Authors:  Bingqi Tong; Jessica N Spradlin; Luiz F T Novaes; Erika Zhang; Xirui Hu; Malte Moeller; Scott M Brittain; Lynn M McGregor; Jeffrey M McKenna; John A Tallarico; Markus Schirle; Thomas J Maimone; Daniel K Nomura
Journal:  ACS Chem Biol       Date:  2020-06-25       Impact factor: 5.100

10.  Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.

Authors:  Carl C Ward; Jordan I Kleinman; Scott M Brittain; Patrick S Lee; Clive Yik Sham Chung; Kenneth Kim; Yana Petri; Jason R Thomas; John A Tallarico; Jeffrey M McKenna; Markus Schirle; Daniel K Nomura
Journal:  ACS Chem Biol       Date:  2019-05-13       Impact factor: 5.100
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