Literature DB >> 28777161

Lack of joint hypermobility increases the risk of surgery in adolescent idiopathic scoliosis.

Gabe Haller1, Hannah Zabriskie1, Shelby Spehar1, Timothy Kuensting1, Xavier Bledsoe1, Ali Syed1, Christina A Gurnett1,2,3, Matthew B Dobbs1.   

Abstract

Generalized joint hypermobility (GJH) is a risk factor for developing adolescent idiopathic scoliosis (AIS); however, it is not known whether joint hypermobility influences the risk of progression to surgery. Beighton joint hypermobility scores were assessed in 570 female AIS patients. Multivariate analysis was carried out to determine whether Beighton hypermobility scores were predictors of surgical intervention. In this female AIS cohort, 24.7% (141/570) had GJH (Beighton score ≥4). Multivariate analysis showed that GJH did not influence the risk of surgery, although having no joint hypermobility (Beighton score=0) increased risk (odds ratio: 1.89; P=0.003). Females who had no hypermobility (score=0) had significantly larger curves than individuals who scored at least one point on the Beighton scale [50° (interquartile range: 26) vs. 42° (interquartile range: 24), P=0.001]. Evaluation of specific measures of joint hypermobility indicated that females who could not touch their palms to the floor were 2.1-fold more likely to have surgery than patients who could perform this task (P=0.001). None of the other features measured on the Beighton score correlated with surgical risk. The lack of joint hypermobility increases the odds of surgery in females with AIS. Specifically, inability to touch the palms to the floor is an indicator of progression to surgery.

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Year:  2018        PMID: 28777161      PMCID: PMC5790620          DOI: 10.1097/BPB.0000000000000489

Source DB:  PubMed          Journal:  J Pediatr Orthop B        ISSN: 1060-152X            Impact factor:   1.041


  26 in total

1.  Maturity assessment and curve progression in girls with idiopathic scoliosis.

Authors:  James O Sanders; Richard H Browne; Sharon J McConnell; Susan A Margraf; Timothy E Cooney; David N Finegold
Journal:  J Bone Joint Surg Am       Date:  2007-01       Impact factor: 5.284

2.  The revised Ghent nosology for the Marfan syndrome.

Authors:  Bart L Loeys; Harry C Dietz; Alan C Braverman; Bert L Callewaert; Julie De Backer; Richard B Devereux; Yvonne Hilhorst-Hofstee; Guillaume Jondeau; Laurence Faivre; Dianna M Milewicz; Reed E Pyeritz; Paul D Sponseller; Paul Wordsworth; Anne M De Paepe
Journal:  J Med Genet       Date:  2010-07       Impact factor: 6.318

3.  Predictors of curve flexibility in adolescent idiopathic scoliosis: a retrospective study of 100 patients.

Authors:  Ebrahim Ameri; Hamid Behtash; Bahram Mobini; Ariasb Daraie
Journal:  Acta Med Iran       Date:  2015

4.  Genetic Risk for Aortic Aneurysm in Adolescent Idiopathic Scoliosis.

Authors:  Gabe Haller; David M Alvarado; Marcia C Willing; Alan C Braverman; Keith H Bridwell; Michael Kelly; Lawrence G Lenke; Scott J Luhmann; Christina A Gurnett; Matthew B Dobbs
Journal:  J Bone Joint Surg Am       Date:  2015-09-02       Impact factor: 5.284

5.  A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis.

Authors:  Gabe Haller; David Alvarado; Kevin Mccall; Ping Yang; Carlos Cruchaga; Matthew Harms; Alison Goate; Marcia Willing; Jose A Morcuende; Erin Baschal; Nancy H Miller; Carol Wise; Matthew B Dobbs; Christina A Gurnett
Journal:  Hum Mol Genet       Date:  2015-11-12       Impact factor: 6.150

6.  Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

Authors:  Jillian G Buchan; David M Alvarado; Gabe E Haller; Carlos Cruchaga; Matthew B Harms; Tianxiao Zhang; Marcia C Willing; Dorothy K Grange; Alan C Braverman; Nancy H Miller; Jose A Morcuende; Nelson Leung-Sang Tang; Tsz-Ping Lam; Bobby Kin-Wah Ng; Jack Chun-Yiu Cheng; Matthew B Dobbs; Christina A Gurnett
Journal:  Hum Mol Genet       Date:  2014-05-15       Impact factor: 6.150

7.  Adolescent idiopathic scoliosis, bracing, and the Hueter-Volkmann principle.

Authors:  Frank P Castro
Journal:  Spine J       Date:  2003 May-Jun       Impact factor: 4.166

8.  Prediction of progression of the curve in girls who have adolescent idiopathic scoliosis of moderate severity. Logistic regression analysis based on data from The Brace Study of the Scoliosis Research Society.

Authors:  L E Peterson; A L Nachemson
Journal:  J Bone Joint Surg Am       Date:  1995-06       Impact factor: 5.284

9.  Epidemiology of generalized joint laxity (hypermobility) in fourteen-year-old children from the UK: a population-based evaluation.

Authors:  Jacqui Clinch; Kevin Deere; Adrian Sayers; Shea Palmer; Chris Riddoch; Jonathan H Tobias; Emma M Clark
Journal:  Arthritis Rheum       Date:  2011-09

10.  The differential diagnosis of children with joint hypermobility: a review of the literature.

Authors:  Louise J Tofts; Elizabeth J Elliott; Craig Munns; Verity Pacey; David O Sillence
Journal:  Pediatr Rheumatol Online J       Date:  2009-01-05       Impact factor: 3.054

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  3 in total

1.  Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders.

Authors:  V N Nikolenko; M V Oganesyan; A D Vovkogon; Yu Cao; A A Churganova; M A Zolotareva; E E Achkasov; M V Sankova; N A Rizaeva; M Y Sinelnikov
Journal:  BMC Musculoskelet Disord       Date:  2020-10-08       Impact factor: 2.362

2.  An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment.

Authors:  Zhaoyang Liu; Amro A Hussien; Yunjia Wang; Terry Heckmann; Roberto Gonzalez; Courtney M Karner; Jess G Snedeker; Ryan S Gray
Journal:  Elife       Date:  2021-07-28       Impact factor: 8.140

Review 3.  A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait-A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis.

Authors:  Nelson L S Tang; Matthew B Dobbs; Christina A Gurnett; Yong Qiu; T P Lam; Jack C Y Cheng; Nancy Hadley-Miller
Journal:  Genes (Basel)       Date:  2021-07-01       Impact factor: 4.096

  3 in total

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