| Literature DB >> 28777126 |
Ilan J N Koppen1, Ilse J Broekaert, Michael Wilschanski, Alexandra Papadopoulou, Carmen Ribes-Koninckx, Nikhil Thapar, Frederic Gottrand, Rok Orel, Paolo Lionetti, Marc A Benninga.
Abstract
According to international guidelines, polyethylene glycol (PEG) is the laxative of first choice in the treatment of functional constipation in children, both for disimpaction and for maintenance treatment. PEG acts as an osmotic laxative and its efficacy is dose dependent. PEG is highly effective, has a good safety profile, and is well tolerated by children. Only minor adverse events have been reported. Overall the use of PEG in children has been reported to be safe, although in patients predisposed to water and electrolyte imbalances monitoring of serum electrolytes should be considered.Entities:
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Year: 2017 PMID： 28777126 DOI： 10.1097/MPG.0000000000001704
Source DB: PubMed Journal: J Pediatr Gastroenterol Nutr ISSN： 0277-2116 Impact factor: 2.839