Literature DB >> 28776488

Amino-functionalized mesoporous silica nanoparticles as efficient carriers for anticancer drug delivery.

Yongju He1,2, Liangyu Luo3, Shuquan Liang1, Mengqiu Long2, Hui Xu2.   

Abstract

Amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were synthesized by a post-grafting method and further studied as carriers for doxorubicin hydrochloride (DOX) delivery. The morphology, structure, and property of MSN-NH2 and DOX-loaded MSN-NH2 (DOX@MSN-NH2) were studied using various techniques, such as transmission electron microscopy, Fourier transformed infrared spectroscopy, N2 adsorption-desorption isotherms, and zeta potentials. The drug loading and release profile as well as the in vitro cell cytotoxicity were detaily investigated. The results indicated that the loading content of DOX increased with the decrease of MSN-NH2/DOX mass ratio and/or the increase of amino density. DOX@MSN-NH2 exhibited a pH-dependent drug release, drug release increased as the pH value decreased. Compared with MSN-NH2, which were neglectable cytotoxicity against non-small-cell lung cancer (A549) cells, DOX@MSN-NH2 displayed remarkable cytotoxicity toward A549 cells in dose- and time-dependent manners. It was concluded that the as-synthesized MSN-NH2 could be used as promising drug carriers for cancer therapy.

Entities:  

Keywords:  Mesoporous silica nanoparticle; amino group; carrier; drug delivery; drug loading

Mesh：

Substances：

Year:  2017        PMID： 28776488     DOI： 10.1177/0885328217724638

Source DB:  PubMed          Journal:  J Biomater Appl        ISSN： 0885-3282            Impact factor:   2.646


  7 in total

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Authors:  Sang Jun Kim; Youngbo Choi; Khee Tae Min; Surin Hong
Journal:  Pharmaceutics       Date:  2022-05-04       Impact factor: 6.525

2.  Triantennary GalNAc-Functionalized Multi-Responsive Mesoporous Silica Nanoparticles for Drug Delivery Targeted at Asialoglycoprotein Receptor.

Authors:  Rosemeyre Cordeiro; Ana Carvalho; Luísa Durães; Henrique Faneca
Journal:  Int J Mol Sci       Date:  2022-06-02       Impact factor: 6.208

Review 3.  Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications.

Authors:  Bazla Siddiqui; Asim Ur Rehman; Ihsan-Ul Haq; Amal A Al-Dossary; Abdelhamid Elaissari; Naveed Ahmed
Journal:  Int J Pharm X       Date:  2022-04-19

Review 4.  Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles.

Authors:  Alessandra Nigro; Michele Pellegrino; Marianna Greco; Alessandra Comandè; Diego Sisci; Luigi Pasqua; Antonella Leggio; Catia Morelli
Journal:  Pharmaceutics       Date:  2018-12-01       Impact factor: 6.321

5.  Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA.

Authors:  Sumita Swar; Veronika Máková; Ivan Stibor
Journal:  Materials (Basel)       Date:  2019-09-30       Impact factor: 3.623

6.  Endostatin Genetically Engineered Placental Mesenchymal Stromal Cells Carrying Doxorubicin-Loaded Mesoporous Silica Nanoparticles for Combined Chemo- and Antiangiogenic Therapy.

Authors:  Paz de la Torre; Juan L Paris; Miguel Fernández-de la Torre; María Vallet-Regí; Ana I Flores
Journal:  Pharmaceutics       Date:  2021-02-10       Impact factor: 6.321

7.  A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer.

Authors:  Dandan Sun; Yifang Zou; Liu Song; Shulan Han; Hao Yang; Di Chu; Yun Dai; Jie Ma; Caitriona M O'Driscoll; Zhuo Yu; Jianfeng Guo
Journal:  Acta Pharm Sin B       Date:  2021-06-18       Impact factor: 11.413
  7 in total

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