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Literature DB >> 2877648

The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent.

Abstract

Scrapie-associated fibrils (SAF) play a controversial role in the discussion about the nature of the scrapie agent. In purification experiments SAF can be detected in brains of infected animals but not in spleen samples with similar titers of infectivity. Thus, SAF are not a constituent of the scrapie virus.

Entities: Disease

Mesh：

Substances：

Year: 1986 PMID： 2877648 DOI： 10.1007/bf01314297

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

18 in total

1. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations.

Authors: R Rubenstein; R J Kascsak; P A Merz; M C Papini; R I Carp; N K Robakis; H M Wisniewski
Journal: J Gen Virol Date: 1986-04 Impact factor: 3.891

2. Pathogenesis of scrapie virus infection in the mouse.

Authors: C M Eklund; R C Kennedy; W J Hadlow
Journal: J Infect Dis Date: 1967-02 Impact factor: 5.226

3. Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.

Authors: N K Robakis; P R Sawh; G C Wolfe; R Rubenstein; R I Carp; M A Innis
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

4. Antibodies to protein of scrapie-associated fibrils.

Authors: H Diringer; H C Rahn; L Bode
Journal: Lancet Date: 1984-08-11 Impact factor: 79.321

5. Infection-specific particle from the unconventional slow virus diseases.

Authors: P A Merz; R G Rohwer; R Kascsak; H M Wisniewski; R A Somerville; C J Gibbs; D C Gajdusek
Journal: Science Date: 1984-07-27 Impact factor: 47.728

6. Purification and structural studies of a major scrapie prion protein.

Authors: S B Prusiner; D F Groth; D C Bolton; S B Kent; L E Hood
Journal: Cell Date: 1984-08 Impact factor: 41.582

7. Scrapie prions aggregate to form amyloid-like birefringent rods.

Authors: S B Prusiner; M P McKinley; K A Bowman; D C Bolton; P E Bendheim; D F Groth; G G Glenner
Journal: Cell Date: 1983-12 Impact factor: 41.582

8. Characterization of antisera against scrapie-associated fibrils (SAF) from affected hamster and cross-reactivity with SAF from scrapie-affected mice and from patients with Creutzfeldt-Jakob disease.

Authors: L Bode; M Pocchiari; H Gelderblom; H Diringer
Journal: J Gen Virol Date: 1985-11 Impact factor: 3.891

9. Characteristics of a short incubation model of scrapie in the golden hamster.

Authors: R H Kimberlin; C Walker
Journal: J Gen Virol Date: 1977-02 Impact factor: 3.891

10. Scrapie: concept of a virus-induced amyloidosis of the brain.

Authors: H R Braig; H Diringer
Journal: EMBO J Date: 1985-09 Impact factor: 11.598

6 in total

1. Scrapie: Report of an outbreak and brief review.

Authors: L Petrie; B Heath; D Harold
Journal: Can Vet J Date: 1989-04 Impact factor: 1.008

Review 2. Transmissible spongiform encephalopathies (TSE) virus-induced amyloidoses of the central nervous system (CNS).

Authors: H Diringer
Journal: Eur J Epidemiol Date: 1991-09 Impact factor: 8.082

Review 3. Prion liposomes.

Authors: R Gabizon; S B Prusiner
Journal: Biochem J Date: 1990-02-15 Impact factor: 3.857

4. Improvement of PrPSc-detection in mouse spleen early at the preclinical stage of scrapie with collagenase-completed tissue homogenization and Sarkosyl-NaCl extraction of PrPSc.

Authors: K U Grathwohl; M Horiuchi; N Ishiguro; M Shinagawa
Journal: Arch Virol Date: 1996 Impact factor: 2.574

Review 5. The molecular mechanisms of scrapie encephalopathy and relevance to human neurodegenerative disease.

Authors: W J Lukiw; H J Cho; J C Kaufmann; D R Crapper McLachlan
Journal: Can J Vet Res Date: 1990-01 Impact factor: 1.310

Review 6. Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology.

Authors: C Darcel
Journal: Vet Res Commun Date: 1995 Impact factor: 2.459

6 in total