Daisuke Fukui1, Mamoru Kawakami2, Tomonori Matsumoto3, Mitsuru Naiki3. 1. Spine Care Center, Wakayama Medical University Kihoku Hospital, 219, Myouji, Katsuragicho, Ito Gun, Wakayama, Japan. taiga26@zeus.eonet.ne.jp. 2. Spine Care Center, Wakayama Medical University Kihoku Hospital, 219, Myouji, Katsuragicho, Ito Gun, Wakayama, Japan. 3. Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., 442-1, Kinashi, Katou, Hyogo, Japan.
Abstract
PURPOSE: Although psychological factors are assumed to be the primary cause of stress-related back pain, there have been no studies of the relationships between stress and low back pain in an animal model. The purpose of this study was to examine the influence of specific alternation of rhythm in temperature (SART) stress on gait abnormality using the CatWalk method in a rat model of low back pain caused by lumbar facetectomy. METHODS: Sixty rats were divided into three groups: the control, sham and experimental groups. Each group was then divided into non-SART stress and SART stress subgroups. We evaluated the behavioral changes 7 weeks postoperatively using the von Frey test and the CatWalk method. RESULTS: Threshold values for the hind paw in the SART stress subgroups were significantly lower than those in the non-SART stress subgroups. In the experimental group, significant changes by CatWalk in step cycle, stand time and average speed were observed under non-SART stress conditions, but SART stress resulted in additional significant changes in not only these parameters, but in other parameters including the duty cycle and swing time, compared with those in the control and sham groups. CONCLUSIONS: The demonstration by CatWalk analysis may indicate that SART stress enhanced gait disturbance. In this animal model, we demonstrated for the first time that stress may be a factor involved in worsening of low back pain.
PURPOSE: Although psychological factors are assumed to be the primary cause of stress-related back pain, there have been no studies of the relationships between stress and low back pain in an animal model. The purpose of this study was to examine the influence of specific alternation of rhythm in temperature (SART) stress on gait abnormality using the CatWalk method in a rat model of low back pain caused by lumbar facetectomy. METHODS: Sixty rats were divided into three groups: the control, sham and experimental groups. Each group was then divided into non-SART stress and SART stress subgroups. We evaluated the behavioral changes 7 weeks postoperatively using the von Frey test and the CatWalk method. RESULTS: Threshold values for the hind paw in the SART stress subgroups were significantly lower than those in the non-SART stress subgroups. In the experimental group, significant changes by CatWalk in step cycle, stand time and average speed were observed under non-SART stress conditions, but SART stress resulted in additional significant changes in not only these parameters, but in other parameters including the duty cycle and swing time, compared with those in the control and sham groups. CONCLUSIONS: The demonstration by CatWalk analysis may indicate that SART stress enhanced gait disturbance. In this animal model, we demonstrated for the first time that stress may be a factor involved in worsening of low back pain.
Entities:
Keywords:
CatWalk method; Descending inhibitory pathway; Intervertebral disc degeneration; Low back pain; SART stress; Von Frey test
Authors: Haobo Jia; Shaowen Zhu; Jianxiong Ma; Jie Wang; Rui Feng; Dan Xing; Yang Yang; Baoyi Ma; Yang Chen; Jingtao Yu; Xinlong Ma Journal: Proc Inst Mech Eng H Date: 2013-05-21 Impact factor: 1.617
Authors: A Bozkurt; R Deumens; J Scheffel; D M O'Dey; J Weis; E A Joosten; T Führmann; G A Brook; N Pallua Journal: J Neurosci Methods Date: 2008-06-03 Impact factor: 2.390
Authors: Mauro Alini; Stephen M Eisenstein; Keita Ito; Christopher Little; A Annette Kettler; Koichi Masuda; James Melrose; Jim Ralphs; Ian Stokes; Hans Joachim Wilke Journal: Eur Spine J Date: 2007-07-14 Impact factor: 3.134