Literature DB >> 28775526

T HELPER SUBSETS AND INTERLEUKIN 12: ITS ROLE AS A POTENT IMMUNOMODULATOR OF CELL MEDIATED IMMUNITY.

P K Menon1, V C Ohri2.   

Abstract

This article reviews Interleukin (IL) IL-12 a recently described cytokine secreted by monocyte/macrophages and its interaction with T cells. IL 12 is important in the immune response by providing a link between natural resistance mediated by phagocytic cells and NK cells and adaptive immunity mediated by T4, T8 and B cells. The article also evaluates the effect of IL12 in the evolution of T helper cell subsets, its action as a bridge between innate immunity and acquired immunity and the important role it plays in modulating the cellular and humoral immune response mechanisms. Its possible role as an immunomodulator of disease is postulated.

Entities:  

Keywords:  CIMI; IL-12; Immunomodulation; T cells

Year:  2017        PMID： 28775526      PMCID： PMC5531631          DOI： 10.1016/S0377-1237(17)30600-7

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN： 0377-1237


  10 in total

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Journal:  Annu Rev Immunol       Date:  1995       Impact factor: 28.527

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Journal:  J Immunol       Date:  1996-04-15       Impact factor: 5.422

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Journal:  Science       Date:  1994-01-14       Impact factor: 47.728

6.  Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

Authors:  R T Gazzinelli; S Hieny; T A Wynn; S Wolf; A Sher
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

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Authors:  M K Gately; M J Brunda
Journal:  Gan To Kagaku Ryoho       Date:  1996-07

8.  IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.

Authors:  I P Oswald; P Caspar; D Jankovic; T A Wynn; E J Pearce; A Sher
Journal:  J Immunol       Date:  1994-08-15       Impact factor: 5.422

9.  Predominance of TH1 response in tumor-bearing mice and cancer patients treated with AS101.

Authors:  B Sredni; T Tichler; A Shani; R Catane; B Kaufman; G Strassmann; M Albeck; Y Kalechman
Journal:  J Natl Cancer Inst       Date:  1996-09-18       Impact factor: 13.506

10.  T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons.

Authors:  J Estaquier; T Idziorek; W Zou; D Emilie; C M Farber; J M Bourez; J C Ameisen
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307
  10 in total

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