Literature DB >> 28774373

[Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia].

Jin-Yun Xu1, Jian-Ming Luo.   

Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children have poor response to glucocorticoids. Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene, and BIM gene is associated with glucocorticoid resistance in childhood ALL. This article reviews the recent studies on glucocorticoid resistance in childhood ALL, especially the role of BIM and its expression products in this process.

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Year:  2017        PMID： 28774373      PMCID： PMC7390050     

Source DB:  PubMed          Journal:  Zhongguo Dang Dai Er Ke Za Zhi        ISSN： 1008-8830


  44 in total

Review 1.  Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia.

Authors:  Vivek A Bhadri; Toby N Trahair; Richard B Lock
Journal:  J Paediatr Child Health       Date:  2011-11-03       Impact factor: 1.954

2.  The mTORC1/2 Inhibitor AZD8055 Strengthens the Efficiency of the MEK Inhibitor Trametinib to Reduce the Mcl-1/[Bim and Puma] ratio and to Sensitize Ovarian Carcinoma Cells to ABT-737.

Authors:  Cécile Pétigny-Lechartier; Charlène Duboc; Abdelghani Jebahi; Marie-Hélène Louis; Edwige Abeilard; Christophe Denoyelle; Pascal Gauduchon; Laurent Poulain; Marie Villedieu
Journal:  Mol Cancer Ther       Date:  2016-12-15       Impact factor: 6.261

3.  BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia.

Authors:  Nan Jiang; Grace Shimin Koh; Joshua Yew Lim; Shirley Kow Kham; Hany Ariffin; Fook Tim Chew; Allen Eng Yeoh
Journal:  Exp Hematol       Date:  2010-12-02       Impact factor: 3.084

4.  Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and -resistant acute lymphoblastic leukemia CEM cells.

Authors:  Ya-ning Zhao; Xia Guo; Zhi-gui Ma; Ling Gu; Jiao Ge; Qiang Li
Journal:  Med Oncol       Date:  2010-08-10       Impact factor: 3.064

5.  Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis.

Authors:  Ling Gu; Chenyan Zhou; Huajun Liu; Ju Gao; Qiang Li; Dezhi Mu; Zhigui Ma
Journal:  J Exp Clin Cancer Res       Date:  2010-11-18

6.  Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

Authors:  T Liu; R J Kishton; A N Macintyre; V A Gerriets; H Xiang; X Liu; E D Abel; D Rizzieri; J W Locasale; J C Rathmell
Journal:  Cell Death Dis       Date:  2014-10-16       Impact factor: 8.469

7.  IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study.

Authors:  Yunlei Li; Jessica G C A M Buijs-Gladdines; Kirsten Canté-Barrett; Andrew P Stubbs; Eric M Vroegindeweij; Willem K Smits; Ronald van Marion; Winand N M Dinjens; Martin Horstmann; Roland P Kuiper; Rogier C Buijsman; Guido J R Zaman; Peter J van der Spek; Rob Pieters; Jules P P Meijerink
Journal:  PLoS Med       Date:  2016-12-20       Impact factor: 11.069

8.  Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia.

Authors:  Sheila Xinxuan Soh; Joshua Yew Suang Lim; John W J Huang; Nan Jiang; Allen Eng Juh Yeoh; S Tiong Ong
Journal:  PLoS One       Date:  2014-08-04       Impact factor: 3.240

9.  Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.

Authors:  C Reynolds; J E Roderick; J L LaBelle; G Bird; R Mathieu; K Bodaar; D Colon; U Pyati; K E Stevenson; J Qi; M Harris; L B Silverman; S E Sallan; J E Bradner; D S Neuberg; A T Look; L D Walensky; M A Kelliher; A Gutierrez
Journal:  Leukemia       Date:  2014-02-20       Impact factor: 11.528

10.  HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia.

Authors:  K Akahane; T Sanda; M R Mansour; T Radimerski; D J DeAngelo; D M Weinstock; A T Look
Journal:  Leukemia       Date:  2015-08-12       Impact factor: 11.528
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