Philipp M Keune1, Sascha Hansen2, Emily Weber3, Franziska Zapf2, Juliane Habich3, Jana Muenssinger3, Sebastian Wolf4, Michael Schönenberg4, Patrick Oschmann3. 1. Klinikum Bayreuth GmbH, Department of Neurology, Bayreuth, Germany; Department of Physiological Psychology, University of Bamberg, Germany. Electronic address: pmkeune@gmail.com. 2. Klinikum Bayreuth GmbH, Department of Neurology, Bayreuth, Germany; Department of Physiological Psychology, University of Bamberg, Germany. 3. Klinikum Bayreuth GmbH, Department of Neurology, Bayreuth, Germany. 4. Department of Clinical Psychology, University of Tübingen, Germany.
Abstract
OBJECTIVE: Neurophysiologic monitoring parameters related to cognition in Multiple Sclerosis (MS) are sparse. Previous work reported an association between magnetoencephalographic (MEG) alpha-1 activity and information processing speed. While this remains to be replicated by more available electroencephalographic (EEG) methods, also other established EEG markers, e.g. the slow-wave/fast-wave ratio (theta/beta ratio), remain to be explored in this context. METHODS: Performance on standard tests addressing information processing speed and attention (Symbol-Digit Modalities Test, SDMT; Test of Attention Performance, TAP) was examined in relation to resting-state EEG alpha-1 and alpha-2 activity and the theta/beta ratio in 25MS patients. RESULTS: Increased global alpha-1 and alpha-2 activity and an increased frontal theta/beta ratio (pronounced slow-wave relative to fast-wave activity) were associated with lower SDMT processing speed. In an exploratory analysis, clinically impaired attention was associated with a significantly increased frontal theta/beta ratio whereas alpha power did not show sensitivity to clinical impairment. CONCLUSIONS: EEG global alpha power and the frontal theta/beta ratio were both associated with attention. The theta/beta ratio involved potential clinical sensitivity. SIGNIFICANCE: Resting-state EEG recordings can be obtained during the routine clinical process. The examined resting-state measures may represent feasible monitoring parameters in MS. This notion should be explored in future intervention studies.
OBJECTIVE: Neurophysiologic monitoring parameters related to cognition in Multiple Sclerosis (MS) are sparse. Previous work reported an association between magnetoencephalographic (MEG) alpha-1 activity and information processing speed. While this remains to be replicated by more available electroencephalographic (EEG) methods, also other established EEG markers, e.g. the slow-wave/fast-wave ratio (theta/beta ratio), remain to be explored in this context. METHODS: Performance on standard tests addressing information processing speed and attention (Symbol-Digit Modalities Test, SDMT; Test of Attention Performance, TAP) was examined in relation to resting-state EEG alpha-1 and alpha-2 activity and the theta/beta ratio in 25MS patients. RESULTS: Increased global alpha-1 and alpha-2 activity and an increased frontal theta/beta ratio (pronounced slow-wave relative to fast-wave activity) were associated with lower SDMT processing speed. In an exploratory analysis, clinically impaired attention was associated with a significantly increased frontal theta/beta ratio whereas alpha power did not show sensitivity to clinical impairment. CONCLUSIONS: EEG global alpha power and the frontal theta/beta ratio were both associated with attention. The theta/beta ratio involved potential clinical sensitivity. SIGNIFICANCE: Resting-state EEG recordings can be obtained during the routine clinical process. The examined resting-state measures may represent feasible monitoring parameters in MS. This notion should be explored in future intervention studies.
Keywords:
Attention; Multiple sclerosis (MS); Resting-state electroencephalogram (EEG); Symbol digit modalities test (SDMT); Test of attention performance (TAP); Theta/beta ratio
Authors: Philipp M Keune; Sascha Hansen; Torsten Sauder; Sonja Jaruszowic; Christina Kehm; Jana Keune; Emily Weber; Michael Schönenberg; Patrick Oschmann Journal: Neuroimage Clin Date: 2019-02-11 Impact factor: 4.881
Authors: Dana van Son; Mischa de Rover; Frances M De Blasio; Willem van der Does; Robert J Barry; Peter Putman Journal: Ann N Y Acad Sci Date: 2019-07-16 Impact factor: 5.691
Authors: M Vazquez-Marrufo; E Sarrias-Arrabal; R Martin-Clemente; A Galvao-Carmona; G Navarro; G Izquierdo Journal: Sci Rep Date: 2020-11-26 Impact factor: 4.379