Literature DB >> 28772115

Unc13 Aligns SNAREs and Superprimes Synaptic Vesicles.

Mark T Palfreyman1, Erik M Jorgensen2.   

Abstract

Unc13 proteins are required for vesicle docking and priming during exocytosis. In this issue of Neuron, Lai et al. (2017) demonstrate that Unc13 ensures that the SNAREs assemble into functional subcomplexes. In a second manuscript, Michelassi et al. (2017) identify a previously unknown autoinhibited state for Unc13 mediated by the tandem C1 and C2 domains.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  C. elegans; Munc13; SNAREs; UNC-13; biochemistry; docking; priming; superpriming; synaptic transmission; synaptic vesicle

Mesh：

Substances：

Year:  2017        PMID： 28772115     DOI： 10.1016/j.neuron.2017.07.017

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  8 in total

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7.  The M domain in UNC-13 regulates the probability of neurotransmitter release.

Authors:  Haowen Liu; Lei Li; Seema Sheoran; Yi Yu; Janet E Richmond; Jingyao Xia; Jing Tang; Jie Liu; Zhitao Hu
Journal:  Cell Rep       Date:  2021-03-09       Impact factor: 9.423

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Journal:  Brain       Date:  2022-07-29       Impact factor: 15.255
  8 in total

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