Miguel A González-Gay1, Carlomaurizio Montecucco2, Albert Selva-O'Callaghan3, Ernesto Trallero-Araguas3, Ovynd Molberg4, Helena Andersson4, Jorge Rojas-Serrano5, Diana Isabel Perez-Roman5, Jutta Bauhammer6, Christoph Fiehn6, Rossella Neri7, Simone Barsotti7, Hannes M Lorenz8, Andrea Doria9, Anna Ghirardello9, Florenzo Iannone10, Margherita Giannini10, Franco Franceschini11, Ilaria Cavazzana11, Konstantinos Triantafyllias12, Maurizio Benucci13, Maria Infantino14, Mariangela Manfredi14, Fabrizio Conti15, Andreas Schwarting16, Giandomenico Sebastiani17, Annamaria Iuliano17, Giacomo Emmi18, Elena Silvestri18, Marcello Govoni19, Carlo Alberto Scirè19, Federica Furini19, Francisco Javier Lopez-Longo20, Julia Martínez-Barrio20, Marco Sebastiani21, Andreina Manfredi21, Javier Bachiller-Corral22, Walter Alberto Sifuentes Giraldo22, Marco A Cimmino23, Claudio Cosso23, Alessandro Belotti Masserini24, Giovanni Cagnotto25, Veronica Codullo2, Mariaeva Romano2, Giuseppe Paolazzi26, Raffaele Pellerito27, Lesley Ann Saketkoo28, Norberto Ortego-Centeno29, Luca Quartuccio30, Alberto Batticciotto31, Elena Bartoloni Bocci32, Roberto Gerli32, Christof Specker33, Elena Bravi34, Carlo Selmi35, Simone Parisi36, Fausto Salaffi37, Federica Meloni38, Enrico Marchioni39, Alberto Pesci40, Giulia Dei40, Marco Confalonieri41, Paola Tomietto42, Laura Nuno43, Francesco Bonella44, Nicolò Pipitone45, Antonio Mera-Valera46, Nair Perez-Gomez46, Simone Gerzeli47, Raquel Lopez-Mejias1, Carlo Jorge Matos-Costa48, Jose Antonio Pereira da Silva48, José Cifrian49, Claudia Alpini50, Ignazio Olivieri51, María Ángeles Blázquez Cañamero52, Ana Belén Rodriguez Cambrón52, Santos Castañeda53, Lorenzo Cavagna54. 1. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain. 2. Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy. 3. Internal Medicine Department, Vall d'Hebron General Hospital, Barcelona, Spain. 4. Department of Rheumatology, Oslo University Hospital (OUH), Oslo, Norway. 5. Interstitial Lung Disease and Rheumatology Units, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México. 6. ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany. 7. Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Italy. 8. Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Germany. 9. Division of Rheumatology, Department of Medicine (DIMED), University of Padova, Italy. 10. Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Italy. 11. Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy. 12. ACURA Rheumatology Center, Bad Kreuznach, Germany. 13. Rheumatology Unit, Azienda Sanitaria di Firenze, S. Giovanni di Dio Hospital, Florence, Italy. 14. Immunology and Allergy Laboratory, S.Giovanni di Dio Hospital, Florence, Italy. 15. Department of Internal Medicine and Medical Specialties-Rheumatology, Sapienza University of Rome, Italy. 16. Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany. 17. U.O.C. Reumatologia, Ospedale San Camillo-Forlanini, Roma, Italy. 18. Department of Experimental and Clinical Medicine, University of Florence, Italy. 19. UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Italy. 20. Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain. 21. Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Italy. 22. Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain. 23. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy. 24. ASST Bergamo Ovest, UOC Medicina, Ospedale di Treviglio, Italy. 25. Lund University, Skane University Hospital, Department of Clinical Sciences, Rheumatology, Lund, Sweden. 26. Rheumatology Unit, Santa Chiara Hospital, Trento, Italy. 27. Division of Rheumatology, Mauriziano Hospital , Turin, Italy. 28. Tulane University Lung Center Tulane, UMC Scleroderma and Sarcoidosis Patient Care and Research Center New Orleans, LA, USA. 29. Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain. 30. Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, Udine, Italy. 31. Rheumatology Unit, Luigi Sacco University Hospital, Milan, Italy. 32. Rheumatology Unit, Department of Medicine, University of Perugia, Italy. 33. Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany. 34. Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy. 35. Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milano, Italy. 36. Rheumatology Department, Città Della Salute e della Scienza, Torino, Italy. 37. Rheumatology Department, Polytechnic University of Marche, C. Urbani Hospital, Jesi, Ancona, Italy. 38. Pneumology Unit, Cardiothoracic and Vascular Department, University and IRCCS Policlinico San Matteo Foundation, Pavia, Italy. 39. C. Mondino National Neurological Institute, Pavia, Italy. 40. School of Medicine and Surgery, University of Milan-Bicocca, Respiratory Unit, ASST Monza, Italy. 41. Department of Pneumology and Respiratory Intermediate Care Unit, University Hospital of Cattinara, Trieste, Italy. 42. Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Italy. 43. Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain. 44. Interstitial and Rare Lung Disease Unit, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany. 45. Rheumatology Unit, Department of Internal Medicine, S.Maria Hospital, IRCCS, Reggio Emilia, Italy. 46. Division of Rheumatology, Instituto de Investigación Sanitaria, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. 47. Department of Political and Social Sciences, Social Statistic studies, University of Pavia, Italy. 48. Rheumatology Unit, Centro Hospitalar e Universitário de Coimbra, Portugal. 49. Division of Pneumology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain. 50. Laboratory of Biochemical-Clinical Analyses, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. 51. Rheumatology Institute of Lucania (IRel), Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, and Basilicata Biomedica (BRB) Foundation, Italy. 52. Rheumatology Unit, Severo Ochoa Hospital, Madrid, Spain. 53. Rheumatology Department, Hospital Universitario de la Princesa, IIS-IP, Madrid, Spain. 54. Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy. lorenzo.cavagna@unipv.it.
Abstract
OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). RESULTS: 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). CONCLUSIONS: In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility.
OBJECTIVES: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD). METHODS: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). RESULTS: 445 (70%; 334 females, 110 males, 1 transsexual) out of the 636 ASSD we collected had arthritis, in the majority of cases (367, 83%) from disease onset (Group 1). Patients belonging to Group 1 with respect to Group 2 had an arthritis more commonly polyarticular and symmetrical (p=0.015), IgM-Rheumatoid factor positive (p=0.035), erosions at hands and feet plain x-rays (p=0.036) and more commonly satisfying the 1987 revised classification criteria for rheumatoid arthritis (RA) (p=0.004). Features such as Raynaud's phenomenon, mechanic's hands and fever (e.g. accompanying findings) were more frequently reported in Group 2 (p=0.005). CONCLUSIONS: In ASSD, the timing of appearance with respect to disease onset influences arthritis characteristics. In particular, RA features are more common when arthritis occurs from ASSD onset, suggesting an overlap between RA and ASSD in these patients. When arthritis appears during the follow-up, it is very close to a connective tissue disease-related arthritis. Also, the different prevalence of accompanying features between these two groups is in line with this possibility.
Authors: John B Miller; Sonye K Danoff; Clifton O Bingham; Julie J Paik; Christopher A Mecoli; Eleni Tiniakou; Lisa Christopher-Stine; Jemima Albayda Journal: Clin Rheumatol Date: 2019-02-27 Impact factor: 2.980
Authors: Yang Yang; Yangtengyu Liu; Li Huang; Li Wang; Ke Liu; Meidong Liu; Hui Luo; Xiaoxia Zuo; Yisha Li; Huali Zhang Journal: Biomed Res Int Date: 2019-03-25 Impact factor: 3.411
Authors: Raquel López-Mejías; Sara Remuzgo-Martínez; Fernanda Genre; Verónica Pulito-Cueto; Sonia M Fernández Rozas; Javier Llorca; David Iturbe Fernández; Víctor M Mora Cuesta; Norberto Ortego-Centeno; Nair Pérez Gómez; Antonio Mera-Varela; Julia Martínez-Barrio; Francisco Javier López-Longo; Verónica Mijares; Leticia Lera-Gómez; María Piedad Usetti; Rosalía Laporta; Virginia Pérez; Alicia De Pablo Gafas; María Aránzazu Alfranca González; Jaime Calvo-Alén; Fredeswinda Romero-Bueno; Olga Sanchez-Pernaute; Laura Nuno; Gema Bonilla; Alejandro Balsa; Fernanda Hernández-González; Ignacio Grafia; Sergio Prieto-González; Javier Narvaez; Ernesto Trallero-Araguas; Albert Selva-O'Callaghan; Oreste Gualillo; Santos Castañeda; Lorenzo Cavagna; José M Cifrian; Miguel A González-Gay Journal: Sci Rep Date: 2020-01-29 Impact factor: 4.379
Authors: Domenico Sambataro; Gianluca Sambataro; Francesca Pignataro; Giovanni Zanframundo; Veronica Codullo; Evelina Fagone; Emanuele Martorana; Francesco Ferro; Martina Orlandi; Nicoletta Del Papa; Lorenzo Cavagna; Lorenzo Malatino; Michele Colaci; Carlo Vancheri Journal: Diagnostics (Basel) Date: 2020-04-09