Literature DB >> 28769336

AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS.

P P Varma1, P K Prasher1, H Madan2, Brig Yashpal3.   

Abstract

Over a follow-up period of 6 years, 4 out of 31 live related renal allograft recipients (12.9%) developed azathioprine induced bone marrow suppression. Presentation in 3 patients was with fever and 2 patients also had associated graft dysfunction. All patients had leucopenia, 2 patients in addition had anaemia and one patient had pancytopenia. Bone marrow suppression developed 9.6 months (3.5-16.0 months) following transplantation and recovery followed over a period of 30 (18-49 days) days after withdrawal of the drug. One patient succumbed during the phase of bicytopenia.

Entities:  

Keywords:  Azathioprine; Bone marrow suppression; Kidney transplantation

Year:  2017        PMID： 28769336      PMCID： PMC5530283          DOI： 10.1016/S0377-1237(17)30834-1

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN： 0377-1237


  6 in total

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Authors:  R J Anderson; L A Schafer; D B Olin; T C Eickhoff
Journal:  Am J Med       Date:  1973-04       Impact factor: 4.965

2.  Leukopenia and azathioprine management in renal homotransplantation.

Authors:  H C Haesslein; J C Pierce; H M Lee; D M Hume
Journal:  Surgery       Date:  1972-04       Impact factor: 3.982

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Authors:  R L Myerowitz; A A Medeiros; T F O'Brien
Journal:  Am J Med       Date:  1972-09       Impact factor: 4.965

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Authors:  B P McGrath; L S Ibels; E Raik; M J Hargrave
Journal:  Q J Med       Date:  1975-01

5.  Azathioprine-induced leukopenia--clinical significance in renal transplantation.

Authors:  R Pollak; R A Nishikawa; M F Mozes; O Jonasson
Journal:  J Surg Res       Date:  1980-09       Impact factor: 2.192

6.  Prediction of azathioprine intolerance in transplant patients.

Authors:  K A Fisher; S K Mahajan; J L Hill; F P Stuart; A I Katz
Journal:  Lancet       Date:  1976-04-17       Impact factor: 79.321
  6 in total
  1 in total

1.  The Efficacy of Mycophenolate Mofetil in Remission Maintenance Therapy for Microscopic Polyangiitis and Granulomatosis with Polyangiitis.

Authors:  Jung Yoon Pyo; Lucy Eunju Lee; Sung Soo Ahn; Jason Jungsik Song; Yong Beom Park; Sang Won Lee
Journal:  Yonsei Med J       Date:  2021-06       Impact factor: 2.759
  1 in total

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