VARIABLE RATE IV INFUSION OF MORPHINE AND HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION.

Haemodynamic response to laryngoscopy and tracheal intubation was studied in two groups of 45 patients each. Group I patients received variable rate infusion of morphine for 30 minutes followed by intravenous (IV) bolus dose of diazepam. Group II patients received intramuscular morphine as preanaesthetic premedication and preinduction IV bolus dose of diazepam. The method of induction of GA was same in both the groups. Systolic and diastolic blood pressure (SBP and DBP) mean arterial pressure and pulse-rate were recorded at intubation and at different time intervals upto 10 minutes after intubation. In group I patients, there was no statistically significant increase in pulse-rate and SBP following intubation but transient significant increase in DBP. In group II patients, there was statistically significant increase in pulse-rate, SBP and DBP upto 3 minutes post-intubation. Thus IV infusion of morphine in combination with IV bolus dose of diazepam proved more effective in attenuating haemodynamic response to tracheal intubation.

RCT Entities:   Population Interventions Outcomes