Literature DB >> 28768876

Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design.

Qihui Wang1,2, Jinghua Yan3,2,4,5,6, George Fu Gao2,4,5,6,7,8.   

Abstract

Zika virus (ZIKV) has caused global concern due to its association with neurological complications in newborns and adults. Although no vaccines or antivirals against ZIKV infection have been approved to date, hundreds of monoclonal antibodies (MAbs) have been developed in a short period. Here, we first present a complete picture of the ZIKV MAbs and then focus on the neutralizing mechanisms and immune hot spots uncovered through structural studies, which provide insight for therapeutics and vaccine design.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Zika virus; clinical therapeutics; monoclonal antibodies; neutralizing epitopes; therapeutics; vaccine design

Mesh：

Substances：

Year:  2017        PMID： 28768876      PMCID： PMC5625485          DOI： 10.1128/JVI.01049-17

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring.

Authors:  Shuo Wang; Shuai Hong; Yong-Qiang Deng; Qing Ye; Ling-Zhai Zhao; Fu-Chun Zhang; Cheng-Feng Qin; Zhiheng Xu
Journal:  Cell Res       Date:  2016-12-06       Impact factor: 25.617

2.  Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.

Authors:  Davide F Robbiani; Leonia Bozzacco; Jennifer R Keeffe; Ricardo Khouri; Priscilla C Olsen; Anna Gazumyan; Dennis Schaefer-Babajew; Santiago Avila-Rios; Lilian Nogueira; Roshni Patel; Stephanie A Azzopardi; Lion F K Uhl; Mohsan Saeed; Edgar E Sevilla-Reyes; Marianna Agudelo; Kai-Hui Yao; Jovana Golijanin; Harry B Gristick; Yu E Lee; Arlene Hurley; Marina Caskey; Joy Pai; Thiago Oliveira; Elsio A Wunder; Gielson Sacramento; Nivison Nery; Cibele Orge; Federico Costa; Mitermayer G Reis; Neena M Thomas; Thomas Eisenreich; Daniel M Weinberger; Antonio R P de Almeida; Anthony P West; Charles M Rice; Pamela J Bjorkman; Gustavo Reyes-Teran; Albert I Ko; Margaret R MacDonald; Michel C Nussenzweig
Journal:  Cell       Date:  2017-05-04       Impact factor: 41.582

3.  Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection.

Authors:  Karin Stettler; Martina Beltramello; Diego A Espinosa; Victoria Graham; Antonino Cassotta; Siro Bianchi; Fabrizia Vanzetta; Andrea Minola; Stefano Jaconi; Federico Mele; Mathilde Foglierini; Mattia Pedotti; Luca Simonelli; Stuart Dowall; Barry Atkinson; Elena Percivalle; Cameron P Simmons; Luca Varani; Johannes Blum; Fausto Baldanti; Elisabetta Cameroni; Roger Hewson; Eva Harris; Antonio Lanzavecchia; Federica Sallusto; Davide Corti
Journal:  Science       Date:  2016-07-14       Impact factor: 47.728

Review 4.  The many faces of the flavivirus NS1 protein offer a multitude of options for inhibitor design.

Authors:  Daniel Watterson; Naphak Modhiran; Paul R Young
Journal:  Antiviral Res       Date:  2016-03-02       Impact factor: 5.970

Review 5.  Molecular basis of antibody-mediated neutralization and protection against flavivirus.

Authors:  Lianpan Dai; Qihui Wang; Jianxun Qi; Yi Shi; Jinghua Yan; George F Gao
Journal:  IUBMB Life       Date:  2016-09-07       Impact factor: 3.885

6.  Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody.

Authors:  Lianpan Dai; Jian Song; Xishan Lu; Yong-Qiang Deng; Abednego Moki Musyoki; Huijun Cheng; Yanfang Zhang; Yuan Yuan; Hao Song; Joel Haywood; Haixia Xiao; Jinghua Yan; Yi Shi; Cheng-Feng Qin; Jianxun Qi; George F Gao
Journal:  Cell Host Microbe       Date:  2016-05-02       Impact factor: 21.023

7.  Zika Virus Associated with Microcephaly.

Authors:  Jernej Mlakar; Misa Korva; Nataša Tul; Mara Popović; Mateja Poljšak-Prijatelj; Jerica Mraz; Marko Kolenc; Katarina Resman Rus; Tina Vesnaver Vipotnik; Vesna Fabjan Vodušek; Alenka Vizjak; Jože Pižem; Miroslav Petrovec; Tatjana Avšič Županc
Journal:  N Engl J Med       Date:  2016-02-10       Impact factor: 91.245

Review 8.  Antibody-mediated neutralization of flaviviruses: a reductionist view.

Authors:  Kimberly A Dowd; Theodore C Pierson
Journal:  Virology       Date:  2011-01-20       Impact factor: 3.616

9.  Modified mRNA Vaccines Protect against Zika Virus Infection.

Authors:  Justin M Richner; Sunny Himansu; Kimberly A Dowd; Scott L Butler; Vanessa Salazar; Julie M Fox; Justin G Julander; William W Tang; Sujan Shresta; Theodore C Pierson; Giuseppe Ciaramella; Michael S Diamond
Journal:  Cell       Date:  2017-02-17       Impact factor: 41.582

10.  Influence of prior influenza vaccination on antibody and B-cell responses.

Authors:  Sanae Sasaki; Xiao-Song He; Tyson H Holmes; Cornelia L Dekker; George W Kemble; Ann M Arvin; Harry B Greenberg
Journal:  PLoS One       Date:  2008-08-20       Impact factor: 3.240
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  14 in total

1.  Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.

Authors:  Xu Yang; Jianxun Qi; Ruchao Peng; Lianpan Dai; Ernest A Gould; George F Gao; Po Tien
Journal:  J Virol       Date:  2019-04-03       Impact factor: 5.103

Review 2.  Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo.

Authors:  Matthew Petitt; Takako Tabata; Henry Puerta-Guardo; Eva Harris; Lenore Pereira
Journal:  Curr Opin Virol       Date:  2017-12       Impact factor: 7.090

3.  A Novel Antigenic Site Spanning Domains I and III of the Zika Virus Envelope Glycoprotein Is the Target of Strongly Neutralizing Human Monoclonal Antibodies.

Authors:  Stephen D Graham; Huy A Tu; Benjamin D McElvany; Nancy R Graham; Ariadna Grinyo; Edgar Davidson; Benjamin J Doranz; Sean A Diehl; Aravinda M de Silva; Alena Janda Markmann
Journal:  J Virol       Date:  2021-04-12       Impact factor: 6.549

4.  CD4+ T cells promote humoral immunity and viral control during Zika virus infection.

Authors:  Annie Elong Ngono; Matthew P Young; Maximilian Bunz; Zhigang Xu; Sararat Hattakam; Edward Vizcarra; Jose Angel Regla-Nava; William W Tang; Montarop Yamabhai; Jinsheng Wen; Sujan Shresta
Journal:  PLoS Pathog       Date:  2019-01-24       Impact factor: 6.823

5.  Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies.

Authors:  Emily N Gallichotte; Ellen F Young; Thomas J Baric; Boyd L Yount; Stefan W Metz; Matthew C Begley; Aravinda M de Silva; Ralph S Baric
Journal:  mBio       Date:  2019-09-17       Impact factor: 7.867

6.  Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters.

Authors:  Venkatraman Siddharthan; Jinxin Miao; Arnaud J Van Wettere; Rong Li; Hua Wu; Eddie Sullivan; Jinan Jiao; Jay W Hooper; David Safronetz; John D Morrey; Justin G Julander; Zhongde Wang
Journal:  Viruses       Date:  2019-01-22       Impact factor: 5.048

7.  Human Polyclonal Antibodies Prevent Lethal Zika Virus Infection in Mice.

Authors:  Emilie Branche; Ayo Yila Simon; Nicholas Sheets; Kenneth Kim; Douglas Barker; Anh-Viet T Nguyen; Harpreet Sahota; Matthew Perry Young; Rebecca Salgado; Anila Mamidi; Karla M Viramontes; Trevor Carnelley; Hongyu Qiu; Annie Elong Ngono; Jose Angel Regla-Nava; Mercylia Xevana Susantono; Joan M Valls Cuevas; Kieron Kennedy; Shantha Kodihalli; Sujan Shresta
Journal:  Sci Rep       Date:  2019-07-08       Impact factor: 4.379

8.  Isolation of Monoclonal Antibodies from Zika Virus-Infected Patient Samples.

Authors:  Qihui Wang; Jinghua Yan
Journal:  Methods Mol Biol       Date:  2020

9.  Multimodal assessments of Zika virus immune pathophysiological responses in marmosets.

Authors:  Fok-Moon Lum; Wei Zhang; Kheng-Choon Lim; Benoit Malleret; Teck-Hui Teo; Jun-Jia Koh; Kuan J Lee; Tze-Kwang Chua; Yiu-Wing Kam; Wearn-Xin Yee; Isaac Huen; Jeslin J L Tan; Siti Naqiah Amrun; Bhanu Prakash Kn; Patrick J Cozzone; Laurent Renia; Philip T H Lee; Lisa F P Ng
Journal:  Sci Rep       Date:  2018-11-20       Impact factor: 4.379

Review 10.  Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus.

Authors:  Taryn M Serman; Michaela U Gack
Journal:  Viruses       Date:  2019-10-22       Impact factor: 5.048
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