| Literature DB >> 2876861 |
L I Harrison, D Schuppan, S R Rohlfing, A R Hansen, J F Gerster, C S Hansen, M L Funk, R E Ober.
Abstract
Single doses of 14C-flumequine (a urinary tract antibacterial) were given to rats and dogs. Unchanged drug accounted for more than 80% of the drug in plasma of rats but only 25-50% in plasma of dogs. Although only a small percentage of the dose was excreted in the urine of each species as unchanged drug, a wide differentiation in the urinary metabolite profiles was observed. No significant tissue retention was seen in rats or dogs.Entities:
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Year: 1986 PMID： 2876861
Source DB: PubMed Journal: Drug Metab Dispos ISSN： 0090-9556 Impact factor: 3.922