George Samonis1, Konstantinos Z Vardakas2,3, Sofia Maraki4, Petroula Stamouli5, Viktoria-Eirini Mavromanolaki6, Diamantis P Kofteridis1, Matthew E Falagas2,3,7. 1. a Department of Internal Medicine , University of Crete School of Medicine , Heraklion , Greece. 2. b Alfa Institute of Biomedical Sciences (AIBS) , Athens , Greece. 3. c Department of Internal Medicine, Henry Dunant Hospital Center , Athens , Greece. 4. d Department of Clinical Microbiology , University Hospital of Heraklion , Heraklion, Crete , Greece. 5. e Department of Applied Mathematics and Physics , National Technical University of Athens , Athens , Greece. 6. f University of Crete School of Medicine , Heraklion, Crete , Greece. 7. g Department of Medicine , Tufts University School of Medicine , Boston , MA , USA.
Abstract
OBJECTIVE: To study changes in the susceptibility of Serratia spp. in Crete, Greece (2010-2015). METHODS: Non-duplicate isolates were examined using automated systems. Phenotypic confirmatory tests were applied. RESULTS: Three hundred and seventy-eight Serratia spp. were analyzed. Serratia marcescens (88.3%) was the predominant species. Fluoroquinolones (97.9%), carbapenems (97.4%) and fosfomycin (97.4%) were the most active followed by amikacin (95.5%), piperacillin/tazobactam (94.7%), and trimethoprim/sulfamethoxazole (94.4%). The activity of 3rd and 4th generation cephalosporins was 87-88.6%. The distribution of multi-drug resistant (MDR) strains varied, with a trend towards increasing frequency. ESBL (7.9%), carbapenemase (2.9%), AmpC (2.1%) and aminoglycoside modifying enzyme (10.6%) production were the commonest resistant phenotypes. CONCLUSION: The susceptibility of Serratia spp. varied during the study period a trend towards decreasing susceptibility, especially for non-carbapenem β-lactams and aminoglycosides.
OBJECTIVE: To study changes in the susceptibility of Serratia spp. in Crete, Greece (2010-2015). METHODS: Non-duplicate isolates were examined using automated systems. Phenotypic confirmatory tests were applied. RESULTS: Three hundred and seventy-eight Serratia spp. were analyzed. Serratia marcescens (88.3%) was the predominant species. Fluoroquinolones (97.9%), carbapenems (97.4%) and fosfomycin (97.4%) were the most active followed by amikacin (95.5%), piperacillin/tazobactam (94.7%), and trimethoprim/sulfamethoxazole (94.4%). The activity of 3rd and 4th generation cephalosporins was 87-88.6%. The distribution of multi-drug resistant (MDR) strains varied, with a trend towards increasing frequency. ESBL (7.9%), carbapenemase (2.9%), AmpC (2.1%) and aminoglycoside modifying enzyme (10.6%) production were the commonest resistant phenotypes. CONCLUSION: The susceptibility of Serratia spp. varied during the study period a trend towards decreasing susceptibility, especially for non-carbapenem β-lactams and aminoglycosides.