Literature DB >> 2876711

The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.

J H Connick, T W Stone.   

Abstract

It has been suggested that the neurotoxic properties of quinolinic acid and kainic acid may, at least in part, involve an indirect action on nerve terminals containing glutamate. In the present study it is confirmed that kainate causes the release of endogenous glutamate from rat hippocampal slices, but that quinolinic acid does not share this activity. In addition beta-kainic acid was found to depress the potassium evoked release of endogenous glutamate at relatively high concentrations and this effect may underlie the anticonvulsant properties of this substance.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 2876711     DOI： 10.1016/0006-2952(86)90636-2

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  6 in total

1.  2-chloroadenosine attenuates kainic acid-induced toxicity within the rat straitum: relationship to release of glutamate and Ca2+ influx.

Authors:  B Arvin; L F Neville; J Pan; P J Roberts
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

2.  Inhibition by the adenosine analogue, (R-)-N6-phenylisopropyladenosine, of kainic acid neurotoxicity in rat hippocampus after systemic administration.

Authors:  D G MacGregor; T W Stone
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

3.  The release of glutamate and aspartate from rat brain synaptosomes in response to domoic acid (amnesic shellfish toxin) and kainic acid.

Authors:  J A Brown; M S Nijjar
Journal:  Mol Cell Biochem       Date:  1995-10-04       Impact factor: 3.396

4.  Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.

Authors:  J H Connick; T W Stone
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

5.  Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.

Authors:  J H Connick; T W Stone
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

Review 6.  An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase-Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases.

Authors:  Li Bo; Tan Guojun; Guo Li
Journal:  Front Immunol       Date:  2018-06-15       Impact factor: 7.561
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.