Guro Lindviksmoen Astrup1,2, Tone Rustøen3,4, Kristin Hofsø3,5, Jon Michael Gran6, Kristin Bjordal2,7. 1. Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, Norway. 2. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway. 3. Department of Research and Development, Division of Emergencies and Critical Care, Oslo University Hospital, Norway. 4. Institute of Health and Society, Faculty of Medicine, University of Oslo, Norway. 5. Lovisenberg Diaconal University College, Oslo, Norway. 6. Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo and Oslo University Hospital, Norway. 7. Research Support Services, Oslo University Hospital, Norway.
Abstract
BACKGROUND: Patients with head and neck cancer (HNC) experience diminished quality of life (QOL) during and after treatment. This study examined which characteristics were associated with QOL over time. METHODS: One hundred thirty-three patients with HNC from a study of 534 oncology patients rated physical and mental QOL using the Short Form-12 5 times from the initiation of radiotherapy (RT) through the following 6 months. Linear mixed model analyses examined changes over time and associated characteristics. RESULTS: The QOL deteriorated during RT and gradually improved after completion. Less social support was negatively associated with both physical and mental QOL. Older age, more comorbidities, more psychological symptoms, and concomitant chemotherapy (CTX) were negatively associated with physical QOL. Male sex, less physical symptoms, surgery before RT, and concomitant chemotherapy were positively associated with mental QOL. CONCLUSION: Clinicians can use knowledge on time course and associated characteristics to identify and inform patients at higher risk for diminished QOL.
BACKGROUND:Patients with head and neck cancer (HNC) experience diminished quality of life (QOL) during and after treatment. This study examined which characteristics were associated with QOL over time. METHODS: One hundred thirty-three patients with HNC from a study of 534 oncology patients rated physical and mental QOL using the Short Form-12 5 times from the initiation of radiotherapy (RT) through the following 6 months. Linear mixed model analyses examined changes over time and associated characteristics. RESULTS: The QOL deteriorated during RT and gradually improved after completion. Less social support was negatively associated with both physical and mental QOL. Older age, more comorbidities, more psychological symptoms, and concomitant chemotherapy (CTX) were negatively associated with physical QOL. Male sex, less physical symptoms, surgery before RT, and concomitant chemotherapy were positively associated with mental QOL. CONCLUSION: Clinicians can use knowledge on time course and associated characteristics to identify and inform patients at higher risk for diminished QOL.
Authors: Pann Ei Hnynn Si; Rachel Gair; Tania Barnes; Louese Dunn; Sonia Lee; Steven Ariss; Stephen J Walters; Martin Wilkie; James Fotheringham Journal: PLoS One Date: 2022-09-27 Impact factor: 3.752
Authors: Puja Aggarwal; Katherine A Hutcheson; Adam S Garden; Frank E Mott; Charles Lu; Ryan P Goepfert; Clifton D Fuller; Stephen Y Lai; G Brandon Gunn; Mark S Chambers; Erich M Sturgis; Ehab Y Hanna; Sanjay Shete Journal: Cancer Date: 2021-08-06 Impact factor: 6.860