Literature DB >> 2876654

Can drugs be used to enhance the psychotherapeutic process?

L Grinspoon, J B Bakalar.   

Abstract

Many preindustrial cultures traditionally use certain psychedelic plants to enhance a procedure that resembles psychotherapy--an idea that was also tested in Western psychiatry in the 1950s and 1960s. LSD and related drugs were used to facilitate the production of memories, fantasies and insights and to enhance the therapeutic alliance. The results were inconclusive, and research was largely abandoned after the drugs became difficult to obtain. It may now be possible to revive this research, using new drugs that do not have some of the disadvantages of the old ones. The drug now of most interest is MDMA (3,4-methylenedioxymethamphetamine) a relatively mild and short-acting substance that is said to give a heightened capacity for introspection and intimacy without the perceptual changes, emotional unpredictability, and occasional adverse reactions associated with LSD. Therapists who have used the drug claim that it can enhance the therapeutic alliance by inviting self-disclosure and promoting trust. Whether MDMA fulfills this promise or not, other drugs may eventually prove useful in psychotherapy. Research on their potential should not be curtailed because of fear that they will be subject to illicit abuse.

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Year:  1986        PMID: 2876654     DOI: 10.1176/appi.psychotherapy.1986.40.3.393

Source DB:  PubMed          Journal:  Am J Psychother        ISSN: 0002-9564


  34 in total

1.  Neurotoxicity of methamphetamine and methylenedioxymethamphetamine.

Authors:  L S Seiden; R Lew; J E Malberg
Journal:  Neurotox Res       Date:  2001-01       Impact factor: 3.911

2.  Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy").

Authors:  J Sharkey; D E McBean; P A Kelly
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

Review 3.  Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine.

Authors:  Lee E Dunlap; Anne M Andrews; David E Olson
Journal:  ACS Chem Neurosci       Date:  2018-07-12       Impact factor: 4.418

Review 4.  Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder.

Authors:  Kevin Sean Murnane
Journal:  Behav Pharmacol       Date:  2019-04       Impact factor: 2.293

Review 5.  Translating Molecular and Neuroendocrine Findings in Posttraumatic Stress Disorder and Resilience to Novel Therapies.

Authors:  Jonathan DePierro; Lauren Lepow; Adriana Feder; Rachel Yehuda
Journal:  Biol Psychiatry       Date:  2019-07-24       Impact factor: 13.382

6.  MDMA produces stimulant-like conditioned locomotor activity.

Authors:  L H Gold; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA.

Authors:  L H Gold; C B Hubner; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

8.  Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes.

Authors:  Bruce E Blough; Antonio Landavazo; Ann M Decker; John S Partilla; Michael H Baumann; Richard B Rothman
Journal:  Psychopharmacology (Berl)       Date:  2014-05-07       Impact factor: 4.530

Review 9.  A review of transpersonal theory and its application to the practice of psychotherapy.

Authors:  M C Kasprow; B W Scotton
Journal:  J Psychother Pract Res       Date:  1999

10.  Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.

Authors:  Jakob A Shimshoni; Ilan Winkler; Ezekiel Golan; David Nutt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-09-20       Impact factor: 3.000

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