Linda A Rasch1,2, Maarten Boers3,4, Catherine L Hill3,4, Marieke Voshaar3,4, Wijnanda Hoogland3,4, Maarten de Wit3,4, Caroline Flurey3,4, Bev Davis3,4, Merete Lund Hetland3,4, Cecilie Heegaard Brahe3,4, Laure Gossec3,4, George A Wells3,4, Peter Tugwell3,4, Bindee Kuriya3,4, Niti Goel3,4, Jasvinder A Singh3,4, Cátia Duarte3,4, José Da Silva3,4, Dirkjan van Schaardenburg3,4, Susanna Proudman3,4, Lilian H D van Tuyl. 1. From the Amsterdam Rheumatology and Immunology Center | VU University Medical Center; Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands; Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide, Adelaide, Australia; University of the West of England, Bristol, UK; Copenhagen Center for Arthritis Research and DANBIO, Center for Rheumatology and Spine Diseases, Righospitalet, Glostrup, Denmark; Sorbonne Universités, UPMC Univ Paris 06; AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France; Department of Medicine, University of Ottawa, Ottawa; University of Toronto, Toronto, Ontario, Canada; Quintiles and Duke University School of Medicine, Durham, North Carolina; University of Alabama at Birmingham, Birmingham, Alabama, USA; Faculty of Medicine and Academic Hospital, University of Coimbra, Coimbra, Portugal. l.rasch@vumc.nl. 2. L.A. Rasch, MSc, Amsterdam Rheumatology and Immunology Center | VU University Medical Center; M. Boers, MD, MSc, PhD, Professor, Epidemiology and Biostatistics, VU University Medical Center, and Amsterdam Rheumatology and Immunology Center | Reade; C.L. Hill, MD, Professor, University of Adelaide; M. Voshaar, MSc, Patient Partner; W. Hoogland, MD, Patient Partner; M. de Wit, PhD, Patient Partner; C. Flurey, PhD, University of the West of England; B. Davis, Patient Partner; M.L. Hetland, MD, PhD, Professor, Copenhagen Center for Arthritis Research and DANBIO, Center for Rheumatology and Spine Diseases, Righospitalet; C.H. Brahe, MD, Copenhagen Center for Arthritis Research and DANBIO, Center for Rheumatology and Spine Diseases, Righospitalet; L. Gossec, MD, PhD, Professor, Sorbonne Universités, UPMC Univ Paris 06; AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; G.A. Wells, MD, Professor, University of Ottawa; P. Tugwell, MD, Professor, Department of Medicine, University of Ottawa; B. Kuriya, MD, University of Toronto; N. Goel, MD, Assistant Professor, Quintiles and Duke University School of Medicine; J.A. Singh, MBBS, MPH, Professor, University of Alabama at Birmingham; C. Duarte, MD, Faculty of Medicine and Academic Hospital, University of Coimbra; J. Da Silva, MD, PhD, Professor, Faculty of Medicine and Academic Hospital, University of Coimbra; D. van Schaardenburg, MD, PhD, Professor, Amsterdam Rheumatology and Immunology Center | Reade; S. Proudman, MBBS, Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide; L.H. van Tuyl, PhD, MBA, Amsterdam Rheumatology and Immunology Center | VU University Medical Center. l.rasch@vumc.nl. 3. From the Amsterdam Rheumatology and Immunology Center | VU University Medical Center; Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands; Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide, Adelaide, Australia; University of the West of England, Bristol, UK; Copenhagen Center for Arthritis Research and DANBIO, Center for Rheumatology and Spine Diseases, Righospitalet, Glostrup, Denmark; Sorbonne Universités, UPMC Univ Paris 06; AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France; Department of Medicine, University of Ottawa, Ottawa; University of Toronto, Toronto, Ontario, Canada; Quintiles and Duke University School of Medicine, Durham, North Carolina; University of Alabama at Birmingham, Birmingham, Alabama, USA; Faculty of Medicine and Academic Hospital, University of Coimbra, Coimbra, Portugal. 4. L.A. Rasch, MSc, Amsterdam Rheumatology and Immunology Center | VU University Medical Center; M. Boers, MD, MSc, PhD, Professor, Epidemiology and Biostatistics, VU University Medical Center, and Amsterdam Rheumatology and Immunology Center | Reade; C.L. Hill, MD, Professor, University of Adelaide; M. Voshaar, MSc, Patient Partner; W. Hoogland, MD, Patient Partner; M. de Wit, PhD, Patient Partner; C. Flurey, PhD, University of the West of England; B. Davis, Patient Partner; M.L. Hetland, MD, PhD, Professor, Copenhagen Center for Arthritis Research and DANBIO, Center for Rheumatology and Spine Diseases, Righospitalet; C.H. Brahe, MD, Copenhagen Center for Arthritis Research and DANBIO, Center for Rheumatology and Spine Diseases, Righospitalet; L. Gossec, MD, PhD, Professor, Sorbonne Universités, UPMC Univ Paris 06; AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology; G.A. Wells, MD, Professor, University of Ottawa; P. Tugwell, MD, Professor, Department of Medicine, University of Ottawa; B. Kuriya, MD, University of Toronto; N. Goel, MD, Assistant Professor, Quintiles and Duke University School of Medicine; J.A. Singh, MBBS, MPH, Professor, University of Alabama at Birmingham; C. Duarte, MD, Faculty of Medicine and Academic Hospital, University of Coimbra; J. Da Silva, MD, PhD, Professor, Faculty of Medicine and Academic Hospital, University of Coimbra; D. van Schaardenburg, MD, PhD, Professor, Amsterdam Rheumatology and Immunology Center | Reade; S. Proudman, MBBS, Royal Adelaide Hospital and Discipline of Medicine, University of Adelaide; L.H. van Tuyl, PhD, MBA, Amsterdam Rheumatology and Immunology Center | VU University Medical Center.
Abstract
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) working group on the patients' perspective on remission in rheumatoid arthritis (RA) has been working on this topic since 2010. At OMERACT 2016, progress and preliminary data on validity of measurement instruments for pain, fatigue, and independence in remission in RA were presented, and future directions were explored. METHODS: A special interest group was organized, in which the current data on the patients' perspective on remission were presented. The ongoing study that aimed to validate measurement instruments for pain, fatigue, and independence in a state of low disease activity or remission was presented, and preliminary data on construct validity and discriminative capacity were evaluated cross-sectionally. RESULTS: At OMERACT 2016, the progress of the working group and preliminary data from 142 of the anticipated 300 patients were presented. Selected instruments significantly correlated with the Disease Activity Score in 28 joints (construct validity) and all instruments except 1 discriminated between patients in and patients not in remission. The subsequent discussion mainly focused around 3 points: (1) the formulation of patient perceived remission, (2) the duration of remission, and (3) the measurement of the domain independence. An informal vote indicated a slight preference for working toward modifying the current remission criteria by adding patient-reported outcomes (PRO), or by substituting the patient's global assessment with 1 or more PRO. CONCLUSION: More evidence on measuring patients' perspective on remission in RA is needed before an informed decision can be made regarding development or modification of remission definitions.
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) working group on the patients' perspective on remission in rheumatoid arthritis (RA) has been working on this topic since 2010. At OMERACT 2016, progress and preliminary data on validity of measurement instruments for pain, fatigue, and independence in remission in RA were presented, and future directions were explored. METHODS: A special interest group was organized, in which the current data on the patients' perspective on remission were presented. The ongoing study that aimed to validate measurement instruments for pain, fatigue, and independence in a state of low disease activity or remission was presented, and preliminary data on construct validity and discriminative capacity were evaluated cross-sectionally. RESULTS: At OMERACT 2016, the progress of the working group and preliminary data from 142 of the anticipated 300 patients were presented. Selected instruments significantly correlated with the Disease Activity Score in 28 joints (construct validity) and all instruments except 1 discriminated between patients in and patients not in remission. The subsequent discussion mainly focused around 3 points: (1) the formulation of patient perceived remission, (2) the duration of remission, and (3) the measurement of the domain independence. An informal vote indicated a slight preference for working toward modifying the current remission criteria by adding patient-reported outcomes (PRO), or by substituting the patient's global assessment with 1 or more PRO. CONCLUSION: More evidence on measuring patients' perspective on remission in RA is needed before an informed decision can be made regarding development or modification of remission definitions.