Literature DB >> 28764183

Acquired Inhibitor of Factor VIII Presenting as Delayed Wound Healing.

Sushma Nayar1, Kishore Babu Esakkimuthu Parvathi2, Mayilananthi Kaliannan3, Premlatha Sivasailam4.   

Abstract

Acquired coagulation factor VIII inhibitor leads to a rare disease i.e., acquired haemophilia which is idiopathic in majority of cases and is seen with autoimmune diseases, haematologic and solid tumours, infections, in the post-partum period and also with certain long-term use of drugs like penicillin and its derivatives, phenytoin, sulfa antibiotics, chloramphenicol, methyldopa, chlorpromazine, levodopa, interferon-α, fludarabine, clopidogrel. We report a case here, with acquired Factor VIII (FVIII) inhibitor acquisition which presented with delayed wound healing as a result of protracted bleeding into the wound. The inhibitor was acquired due to prolonged chlorpromazine use.

Entities:  

Keywords:  Chlorpromazine; Idiopathic; Protracted bleeding

Year:  2017        PMID: 28764183      PMCID: PMC5535376          DOI: 10.7860/JCDR/2017/21598.10109

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  11 in total

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Journal:  Clin Adv Hematol Oncol       Date:  2012-01

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Review 5.  Acquired factor VIII inhibitors: pathophysiology and treatment.

Authors:  Alice D Ma; Daniel Carrizosa
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2006

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Authors:  S Zucker; M H Zarrabi; G S Romano; F Miller
Journal:  Br J Haematol       Date:  1978-11       Impact factor: 6.998

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Journal:  Acta Med Scand       Date:  1980

Review 8.  Acquired factor VIII inhibitors.

Authors:  Massimo Franchini; Giuseppe Lippi
Journal:  Blood       Date:  2008-05-07       Impact factor: 22.113

9.  Transient acquired hemophilia associated with Mycoplasma pneumoniae pneumonia.

Authors:  Min Sun Kim; Paul E Kilgore; Ju Sung Kang; Sun Young Kim; Dae Yeol Lee; Jung Soo Kim; Pyoung Han Hwang
Journal:  J Korean Med Sci       Date:  2008-02       Impact factor: 2.153

10.  Postpartum Acquired Hemophilia Factor VIII Inhibitors and Response to Therapy.

Authors:  Volkan Karakuş; Mustafa Celik; Dilek Soysal; Bahriye Payzın
Journal:  Turk J Haematol       Date:  2012-06-15       Impact factor: 1.831

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  1 in total

1.  Acquired Factor VIII Inhibitor Presenting as Occult GI Bleeding.

Authors:  Carlos I Pacheco Cano; Marilyn A Arosemena; Roumen B Iordanov; Ankitha Lingamaneni; Ankur Aneja
Journal:  Case Rep Hematol       Date:  2018-06-19
  1 in total

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