| Literature DB >> 28764082 |
Yao Chen1, Qian Li2, Ting Zhao3, Zhen Zhang1, Guanghua Mao1, Weiwei Feng1, Xiangyang Wu4, Liuqing Yang5.
Abstract
Anthocyanins (ACNs) are naturally occurring components of human diet. Evidence has accumulated regarding the positive association of their intake with chronic disease. Because microbiota has been considered as a metabolic organ, the bacterial-dependent metabolisms of three types of ACNs from mulberry fruits (cyanidin-3-glucoside (C3G), cyanidin-3-rutinoside (C3R), delphinidin-3-rutinoside (D3R)) during a simulation of large intestine conditions were investigated. ACNs and metabolites were analysed and characterized by high performance liquid chromatography-electrospray ionization-mass spectrum (HPLC-ESI-MS/MS). C3G disappeared after 6h of metabolism, while C3R and D3R were no longer detected after 8h. The metabolism of C3G and C3R mainly resulted in the formation of protocatechuic, vanillic, and p-coumaric acids, as well as 2,4,6-trihydroxybenzaldehyde, while the main metabolites of D3R were gallic acid, syringic acid and 2,4,6-trihydroxybenzaldehyde. This research indicated that the intake of ACNs may result in the appearance of specific metabolites that exert a protective effect in the host physiology.Entities:
Keywords: Anthocyanin monomers; Gut microbiota; HPLC-ESI-MS/MS; Metabolism; Phenolic acid
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Year: 2017 PMID： 28764082 DOI： 10.1016/j.foodchem.2017.06.054
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514