Marie Pedersen1, Ester Garne2, Nete Hansen-Nord3, Dorrit Hjortebjerg4, Matthias Ketzel5, Ole Raaschou-Nielsen6, Anne-Marie Nybo Andersen7, Mette Sørensen8. 1. Centre for Epidemiology and Screening, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, 1014 Copenhagen K, Denmark; Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark. Electronic address: mp@sund.ku.dk. 2. Pediatric Department, Hospital Lillebaelt, Skovvangen 2-8, 6000 Kolding, Denmark. Electronic address: Ester.Garne@rsyd.dk. 3. Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark. Electronic address: nsh@dignityinstitute.dk. 4. Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark. Electronic address: dorhjo@cancer.dk. 5. Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark. Electronic address: mke@envs.au.dk. 6. Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark. Electronic address: ole@cancer.dk. 7. Section of Social Medicine, Department of Public Health, University of Copenhagen, Gothersgade 160, 1123 Copenhagen K, Denmark. Electronic address: amny@sund.ku.dk. 8. Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark. Electronic address: mettes@cancer.dk.
Abstract
BACKGROUND: Ambient air pollution has been associated with certain congenital anomalies, but few studies rely on assessment of fine-scale variation in air quality and associations with noise from road traffic are unexplored. METHODS: Among 84,218 liveborn singletons (1997-2002) from the Danish National Birth Cohort with complete covariate data and residential address history from conception until birth, we identified major congenital anomalies in 4018 children. Nitrogen dioxide (NO2) and noise from road traffic (Lden) burden during fetal life was modeled. Outcome and covariate data were derived from registries, hospital records and questionnaires. Odds ratios (ORs) for eleven major anomaly groups associated with road traffic pollution during first trimester were estimated using logistic regression with generalized estimating equation (GEE) approach. RESULTS: Most of the associations tested did not suggest increased risks. A 10-µg/m3 increase in NO2 exposure during first trimester was associated with an adjusted ORs of 1.22 (95% confidence interval: 0.98-1.52) for ear, face and neck anomalies; 1.14 0.98-1.33) for urinary anomalies. A 10-dB increase in road traffic noise was also associated with these subgroups of anomalies as well as with an increased OR for orofacial cleft anomalies (1.17, 0.94-1.47). Inverse associations for several both air pollution and noise were observed for atrial septal defects (0.85, 0.68-1.04 and 0.81, 0.65-0.99, respectively). CONCLUSIONS: Residential road traffic exposure to noise or air pollution during pregnancy did not seem to pose a risk for development of congenital anomalies.
BACKGROUND: Ambient air pollution has been associated with certain congenital anomalies, but few studies rely on assessment of fine-scale variation in air quality and associations with noise from road traffic are unexplored. METHODS: Among 84,218 liveborn singletons (1997-2002) from the Danish National Birth Cohort with complete covariate data and residential address history from conception until birth, we identified major congenital anomalies in 4018 children. Nitrogen dioxide (NO2) and noise from road traffic (Lden) burden during fetal life was modeled. Outcome and covariate data were derived from registries, hospital records and questionnaires. Odds ratios (ORs) for eleven major anomaly groups associated with road traffic pollution during first trimester were estimated using logistic regression with generalized estimating equation (GEE) approach. RESULTS: Most of the associations tested did not suggest increased risks. A 10-µg/m3 increase in NO2 exposure during first trimester was associated with an adjusted ORs of 1.22 (95% confidence interval: 0.98-1.52) for ear, face and neck anomalies; 1.14 0.98-1.33) for urinary anomalies. A 10-dB increase in road traffic noise was also associated with these subgroups of anomalies as well as with an increased OR for orofacial cleft anomalies (1.17, 0.94-1.47). Inverse associations for several both air pollution and noise were observed for atrial septal defects (0.85, 0.68-1.04 and 0.81, 0.65-0.99, respectively). CONCLUSIONS: Residential road traffic exposure to noise or air pollution during pregnancy did not seem to pose a risk for development of congenital anomalies.
Authors: Giehae Choi; Jeanette A Stingone; Tania A Desrosiers; Andrew F Olshan; Wendy N Nembhard; Gary M Shaw; Shannon Pruitt; Paul A Romitti; Mahsa M Yazdy; Marilyn L Browne; Peter H Langlois; Lorenzo Botto; Thomas J Luben Journal: Environ Res Date: 2019-09-10 Impact factor: 6.498
Authors: Jeffrey T White; Erin Kovar; Tiffany M Chambers; Kunj R Sheth; Erin C Peckham-Gregory; Marisol O'Neill; Peter H Langlois; Carolina J Jorgez; Philip J Lupo; Abhishek Seth Journal: Int J Environ Res Public Health Date: 2019-03-15 Impact factor: 3.390