Sahar Razmjou1,2, Joseph Abdulnour1,2, Jean-Philippe Bastard3,4,5, Soraya Fellahi3,4,5, Éric Doucet1,6, Martin Brochu7,8, Jean-Marc Lavoie9, Rémi Rabasa-Lhoret10,11, Denis Prud'homme1,2. 1. School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. 2. Institut du savoir Montfort, Ottawa, ON, Canada. 3. Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Unité Fonctionnelle Bio-marqueurs Inflammatoires et Métaboliques, Service de Biochimie et Hormonologie, Paris, France. 4. Pierre-and-Marie-Curie Sorbonne University, Paris 6, UMR_S 938 CDR-Saint-Antoine, F-75012, Paris, France. 5. University Hospital Institute of Cardiometabolism and Nutrition Institute, Paris, France. 6. Behavioral and Metabolic Research Unit, University of Ottawa, Ottawa, ON, Canada. 7. Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke, QC, Canada. 8. Research Center on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, Sherbrooke, QC, Canada. 9. Départment de kinesiologie, Université de Montréal, Montréal, QC, Canada. 10. Department of Nutrition, Université de Montréal, Montreal, PQ, Canada. 11. Institut de Recherches Cliniques de Montréal (IRCM), Montréal, PQ, Canada.
Abstract
OBJECTIVE: Menopausal transition and postmenopause are usually associated with changes in body composition and a decrease in physical activity energy expenditure (PAEE). This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up. METHODS: In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study. This present substudy included 48 participants (age: 60.0 ± 1.7 years; body mass index: 23.2 ± 2.2 kg/m) 6.0 ± 0.3 years after completion of the initial MONET study. Measures included body composition, waist circumference (WC), fasting glucose and insulin levels, insulin sensitivity (QUICKI model), plasma lipid levels, PAEE, and inflammatory markers. RESULTS: Compared with baseline measures of the MONET study, analyses revealed no significant increase in body weight, although there were significant increases in WC, fat mass (FM), % FM, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, haptoglobin, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 (all P < 0.001) after the 10-year follow-up. However, significant decreases were observed for fat-free mass, PAEE, fasting glucose levels, interleukin-8 levels, and soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2) levels (all P < 0.05). To determine the effect of postmenopausal years, data were restructured based on final menstrual period (FMP), and one-way analyses of variance were performed.Waist circumference, % FM, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 were higher in early and late postmenopausal periods in these women. sTNFR-1 and sTNFR-2 levels were higher at the FMP and early postmenopausal years as compared with the late postmenopausal periods. Finally, interleukin-8 levels were lower in years after FMP. CONCLUSION: The number of years elapsed since the FMP can affect body composition, cardiometabolic risk factors, and inflammatory markers in healthy premenopausal women going through menopausal transition and postmenopausal periods.
OBJECTIVE: Menopausal transition and postmenopause are usually associated with changes in body composition and a decrease in physical activity energy expenditure (PAEE). This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up. METHODS: In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study. This present substudy included 48 participants (age: 60.0 ± 1.7 years; body mass index: 23.2 ± 2.2 kg/m) 6.0 ± 0.3 years after completion of the initial MONET study. Measures included body composition, waist circumference (WC), fasting glucose and insulin levels, insulin sensitivity (QUICKI model), plasma lipid levels, PAEE, and inflammatory markers. RESULTS: Compared with baseline measures of the MONET study, analyses revealed no significant increase in body weight, although there were significant increases in WC, fat mass (FM), % FM, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, haptoglobin, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 (all P < 0.001) after the 10-year follow-up. However, significant decreases were observed for fat-free mass, PAEE, fasting glucose levels, interleukin-8 levels, and soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2) levels (all P < 0.05). To determine the effect of postmenopausal years, data were restructured based on final menstrual period (FMP), and one-way analyses of variance were performed.Waist circumference, % FM, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 were higher in early and late postmenopausal periods in these women. sTNFR-1 and sTNFR-2 levels were higher at the FMP and early postmenopausal years as compared with the late postmenopausal periods. Finally, interleukin-8 levels were lower in years after FMP. CONCLUSION: The number of years elapsed since the FMP can affect body composition, cardiometabolic risk factors, and inflammatory markers in healthy premenopausal women going through menopausal transition and postmenopausal periods.
Authors: Gail A Greendale; Barbara Sternfeld; MeiHua Huang; Weijuan Han; Carrie Karvonen-Gutierrez; Kristine Ruppert; Jane A Cauley; Joel S Finkelstein; Sheng-Fang Jiang; Arun S Karlamangla Journal: JCI Insight Date: 2019-03-07
Authors: Matti Hyvärinen; Hanna-Kaarina Juppi; Sara Taskinen; Jari E Karppinen; Sira Karvinen; Tuija H Tammelin; Vuokko Kovanen; Pauliina Aukee; Urho M Kujala; Timo Rantalainen; Sarianna Sipilä; Eija K Laakkonen Journal: Int J Obes (Lond) Date: 2021-11-20 Impact factor: 5.095